Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not readily biodegradable according to OECD criteria
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
The biodegradation of 1,4-Diazabicyclo[2.2.2]octane was examined in a guideline study according to OECD 301 B (Air Products, 1998). Activated sludge from domestic sources was used as inoculum. Results revealed no significant degradation of the test substance (7% CO2 degradation after 28 d). In the toxicity control, 1,4-Diazabicyclo[2.2.2]Octane was not found to be inhibitory.
Similar results were obtained in a supporting study conducted with non-adapted activated sludge according to OECD 301 B (NITI, 2000). Degradation of the test substance was 0% (CO2 degradation) after 28 days.
The biodegradation of 1,4-Diazabicyclo[2.2.2]octane in water was also estimated using the QSAR method of CATALOGIC 301C v11.16 (OASIS Catalogic v5.14.1.5), which predicted an O2-consumption (BOD) of 25% after 28d (BASF, 2022).
Based on this results, the test substance is considered not readily biodegradable according to OECD criteria.
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