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EC number: 226-394-6
CAS number: 5392-40-5
No immunotoxic effect in host resistance assay and antibody plaque-forming cell assay up to 800 mg/kg bw/d for 5 days by gavage
After a 5-day intragastral application of
citral to groups of 30 CD-1 mice (0, 200, 400, 800 mg/kg bw/d), 20 of
the animals were subjected to a host resistance assay with infection
with Listeria monocytogenes, while humoral immunity was measured by the
antibody plaque-forming cell (PFC) response to sheep erythrocytes in
further 10 mice. Based
on these assays, there was
no indication of an immunotoxic activity of citral.
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