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EC number: 265-191-7
CAS number: 64742-88-7
A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
animals died during the study and no body weight differences occurred.
Very slight to severe dermal irritation occurred during the study at the test
application sites. There were no effects on the haematological or
clinical chemical values measured.
Organ weights were unaffected (absolute and ratios to body or brain weight).
At necropsy apart from skin irritation, there were no other findings.
Histopathology did not reveal any changes that were due to treatment other
than skin changes due to irritation.
a 28-day dermal toxicity study, thermocracked kerosine was applied to
the shaved skin of 10
Sprague-Dawley rats/sex/dose at dose levels of 0, 0.01, 0.05, or 0.5
mL/kg bw/day, 6 hours/day for 5 days/week during a 28-day period.
test compound irritated the skin in a dose-dependent manner. In
the high-dose group, the irritation became severe so the application
site was moved to a cephalad location at the beginning of the fourth
were no compound related effects in mortality, clinical signs, body
weight, haematology, clinical chemistry, organ weights, or gross and
histologic pathology (except the skin). The
LOAEL for dermal irritation is 0.01 mL/kg/day, based on slight to severe
dermal irritation occurring at all doses tested. No
dermal irritation NOAEL was established. There was no systemic LOAEL,
based on the lack of systemic effects. The systemic NOAEL is greater
than or equal to 0.5 mL/kg/day.
study received a Klimisch score of 1 and is classified because
it was conducted according to OECD TG 410.
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