Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-111-0 | CAS number: 148528-05-6
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.71 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 53 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Corrected inhalative systemic NOAEL following route-to route-extrapolation with factors as in guidance R.8: oral NOAEL= 30mg/kg/day *6.7/10/0.38. The high water solubility of MODA, the caustic effects and the partition coefficient log Kow of 2 allowed the assumption of equal distribution in the organisms. As described in chapter 7.1 of this IUCLID file oral and inhalation absorption was taken to 100%. In consequence the route-to-route extrapolation factor is 1. This is confirmed by ECETOC TGD 110. Molecules with a molecular weight < 500 and a log Kow between 0 and 4 can be assumed to be well absorbed equivalently by the oral and inhalation route.
- AF for dose response relationship:
- 1
- Justification:
- guidance R.8 default
- AF for differences in duration of exposure:
- 6
- Justification:
- guidance R.8 default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- guidance R.8 default
- AF for other interspecies differences:
- 1
- Justification:
- guidance R.8 default
- AF for intraspecies differences:
- 5
- Justification:
- guidance R.8 default
- AF for the quality of the whole database:
- 1
- Justification:
- valid study available for point of departure
- AF for remaining uncertainties:
- 2.5
- Justification:
- guidance R.8 default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- A worst case assumption of 100% dermal absorption is used (route to route extrapolation factor 1). Corrosivity and follow up effects were the main symptoms in the oral study.
- AF for dose response relationship:
- 1
- Justification:
- guidance R.8 default
- AF for differences in duration of exposure:
- 6
- Justification:
- guidance R.8 default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- guidance R.8 default
- AF for other interspecies differences:
- 1
- Justification:
- guidance R.8 default
- AF for intraspecies differences:
- 5
- Justification:
- guidance R.8 default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 2.5
- Justification:
- guidance R.8 default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.17 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 26 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Corrected inhalative systemic NOAEL following route-to route-extrapolation with factor 0.87 as in guidance R.8 (oral NOAEL= 30mg/kg/day * 0.87)
- AF for dose response relationship:
- 1
- Justification:
- guidance R.8 default
- AF for differences in duration of exposure:
- 6
- Justification:
- guidance R.8 default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- guidance R.8 default
- AF for other interspecies differences:
- 1
- Justification:
- guidance R.8 default
- AF for intraspecies differences:
- 10
- Justification:
- guidance R.8 default
- AF for the quality of the whole database:
- 1
- Justification:
- guidance R.8 default
- AF for remaining uncertainties:
- 2.5
- Justification:
- guidance R.8 default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- A worst case assumption of 100% dermal absorption is used. Corrosivity and follow up effects were the main symptoms in the oral study.
- AF for dose response relationship:
- 1
- Justification:
- guidance R.8 default
- AF for differences in duration of exposure:
- 6
- Justification:
- guidance R.8 default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- guidance R.8 default
- AF for other interspecies differences:
- 1
- Justification:
- guidance R.8 default
- AF for intraspecies differences:
- 10
- Justification:
- guidance R.8 default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 2.5
- Justification:
- guidance R.8 default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 30 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- guidance R.8 default
- AF for differences in duration of exposure:
- 6
- Justification:
- guidance R.8 default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- guidance R.8 default
- AF for other interspecies differences:
- 1
- Justification:
- guidance R.8 default
- AF for intraspecies differences:
- 10
- Justification:
- guidance R.8 default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 2.5
- Justification:
- guidance R.8 default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
