Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Only one study (Chrysalis, 1995) with reliability 1 was available and was selected as key study. The summary of this study is the following:

In a dermal sensitization study (Chrysalis, 1995) with p-trifluoromethylaniline in absolute ethanol, Hartley guinea pigs (10/sex in test groups and 5/sex in control group) were tested using the method of maximization. 

2/20 animals presented positive reaction. It is not sufficient to consider p-TFMA for sensitization. 30% of positive reaction is necessary to classify a test item as skin sensitizer.

Burnt appearance of the skin on a surface less than one quarter of the application area was noted for 2 males. 1 male and 2 females presented scratches to the application area.

At dose of 1%, p-trifluoromethylaniline was not considered as dermal sensitizer, according to the EC classification criteria (67/548/EC directive) and CLP criteria.

Migrated from Short description of key information:
p-TFMA is not sensitizing at 1% concentration in a maximization test.

Justification for classification or non-classification

Based on results of the available study, p-TFMA could be considered as not sensitizing.