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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
March 1 - May 14, 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate reliability index.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology.
GLP compliance:
no
Test type:
other: In silico prediction.

Test material

Constituent 1
Chemical structure
Reference substance name:
1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
EC Number:
236-138-5
EC Name:
1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
Cas Number:
13185-09-6
Molecular formula:
C14H12N2O.Na
IUPAC Name:
sodium 1-benzyl-3-oxo-2,3-dihydro-1H-indazol-2-ide

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: The acute toxicity overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral toxicity in rat overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).
Predicted LD50 oral in rat = 1300 mg/kg.
The substance is classified as harmful if swallowed.

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