Registration Dossier
Registration Dossier
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EC number: 236-138-5 | CAS number: 13185-09-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- March 1 - May 14, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate reliability index.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- no
- Test type:
- other: In silico prediction.
Test material
- Reference substance name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- EC Number:
- 236-138-5
- EC Name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- Cas Number:
- 13185-09-6
- Molecular formula:
- C14H12N2O.Na
- IUPAC Name:
- sodium 1-benzyl-3-oxo-2,3-dihydro-1H-indazol-2-ide
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The acute toxicity overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity in rat overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).
Predicted LD50 oral in rat = 1300 mg/kg.
The substance is classified as harmful if swallowed.
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