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EC number: 204-398-9
CAS number: 120-46-7
On the basis of the result, interpreted according to OECD 471:1997 and
ISO 10993 -3, the test item "1,3 DYPHENYLPROPANE-1,3 -DIONE" tested as
recommended by Standards, proved to be NOT MUTAGENIC for all the test
strains, either in the presence or absence of metabolic activation.
According to OECD 476:1997 “In Vitro Mammalian Cell Gene Mutation Test”,
under the test conditions applied, the test substance
1,3-Dyphenylpropane-1,3-Dione batch n°131211-E is considered to induce
gene mutations in the cultured mammalian cells used.
According to OECD 487:2010 In vitro mammalian micronucleus test. Under
the test condition 24 hours –S9 the test substance induced chromosome
breakage loss at a concentration of 7,67 μg/ml, in cultured mammalian
Endpoint Conclusion: Adverse effect observed (positive)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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