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EC number: 205-286-2 | CAS number: 137-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC10 (72 h): 56.9 µg a.i./L (geometric mean, OECD 201, static, Pseudokirchnerella subcapitata)
ErC50 (72 h): > 141 µg a.i./L (geometric mean, OECD 201, static, Pseudokirchnerella subcapitata)
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 56.9 µg/L
Additional information
One key study investigating the toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to algae, is available.
Effects of tetramethylthiuram disulfide (CAS No. 137-26-8) on the growth of a freshwater green algae (Pseudokirchneriella subcapitata) applied at 5 dose rates with nominal concentrations of 47, 74, 119, 191 and 304 µg a.s./L was observed over a period of 72 hours in a static test system (OECD 201, GLP). Three replicate flasks at each test concentration, a solvent control and six control replicate flasks (Algal Growth (AAP-) Medium alone) were included in the test. The test item was analytically monitored at time points 0, 24, 48 and 72 h. The analytical verification of the test item confirmed a recovery of Thiram in the test solutions at test termination in a range from 5 to 14% of nominal concentrations. Therefore, the results of the study are based on geometric mean measured concentrations of 20, 29, 43, 75 and 141 µg a.i./L. Concentration dependent effects on growth rate and yield were observed. Exposure of P. subcapitata to the highest concentration of 141 µg/L caused a maximum inhibition of growth rate and yield of 37% and 84%, respectively. The 72-hour EC50 values for growth rate and for yield were calculated to be > 141 µg a.i./L (geom. mean measured) and 69.5 µg a.i./L (geom. mean measured), respectively. The 72-hour EC10 values for growth rate and yield of P. subcapitata were determined as 56.9 µg a.i./L (geom. mean measured) and 28.9 µg a.i./L (geom. mean measured), respectively. NOEC (72 h) values were determined to be 29 µg a.i./L (geom. mean measured) for both growth rate and yield.
Furthermore, one study investigating the toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to algae species with minor reliability (RL3) is available. A reevaluation of the data revealed that not all validity criteria are met according to the recent OECD Guideline No. 201 (version 2011). The mean coefficient of variation for section-by-section specific growth rates (days 0-1, 1-2 and 2-3, for 72-hour tests) in the control cultures reached 68.8% and by that exceeded the maximum of 35%, given as validity criterion in the guideline.
The results from the key study are considered more reliable and were used for the hazard and risk assessment.
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