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EC number: 273-620-4
CAS number: 68990-67-0
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Quillaja saponaria, Rosaceae.
The acutc eye irritation/corrosion of a liquid Quillaja saponaria
extract was tested in three albino rabbits according to US EPA Guideline
EPA OPPTS 870.2400 . The test item was instilled as the original
substance at a single dose of 0.1 ml to one of the eyes in each animal.
The untreated eye was used as control.
The animals were examined for clinical signs and the eyes were
examined for lesions of the conjunctivae, cornea and iris 60 minutes,
24, 48, 72 hours, 7 days and 14 days after instillation of the test
item. The grades for ocular lesions were recorded in accordance with the
Well defined signs of irritation were observed on the treated eyes. All
effects were fully reversible within 14 days.
None of the animals died or showed clinical signs during the
course of testing.
Based on the respective mean scores classification of the test item as
causing serious eye irritation (Cat. 2) is required according to CLP; EU
GHS (Regulation (EC) No 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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