Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 209-943-4 | CAS number: 598-63-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Percutaneous absorption of inorganic lead compounds
- Author:
- Stauber JL, Florence TM, Gulson BL, Dale LS.
- Year:
- 1 994
- Bibliographic source:
- The Science of the Total Environment 145(1-2):55-70
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aim of this study was to monitor the uptake and the transport of skin-absorbed inorganic lead compounds in sweat, urine, and blood of human volunteers using a stable lead isotope enriched in 204Pb.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead carbonate
- EC Number:
- 209-943-4
- EC Name:
- Lead carbonate
- Cas Number:
- 598-63-0
- Molecular formula:
- CH2O3.Pb
- IUPAC Name:
- λ²-lead(2+) carbonate
- Reference substance name:
- PbCO3
- IUPAC Name:
- PbCO3
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
Lead carbonate as showed in preleminary experiments was not absorbed through the skin.
Applicant's summary and conclusion
- Conclusions:
- In the conditions of the studies, lead carbonate was not found toxic through dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
