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EC number: 206-564-6
CAS number: 354-58-5
Table 1: Results of an oral toxicity study with
1,1,2-trichloro-1,2,2-trifluoroethane on rats
Dose [g/kg bw]
Approx. time of death
Average weight change [g]
Remark of the registrant: Table I of the publication has "mg/kg" as unit
for the dose in the column header together with the values 30, 35, 40,
45, 50 and 55 in the corresponding rows. The publication text describes
the administered volumes of the undiluted liquid (density ca. 1.6 g/mL)
and the body weights of the rats and gives explicitly the value for
LD50. From this it can be concluded without any doubt that the unit
cannot be "mg/kg" together with the given dose values. Thus the dose
unit in the column header should read as "g/kg". The table above
reflects this correction.
Acute oral toxicity of 1,1,2-trichloro-1,2,2-trifluoroethan was assessed
in an oral toxicity study on Sprague-Dawley rats. No deaths were
observed up to a concentration of 40 g/kg bw. In the 45 and 50 g/kg bw
groups 3 and 4 animals died, respectively. At a concentration of 55 g/kg
bw all five animals were found dead. Clinical signs included lethargy,
ruffled fur, facial edema, distention of abdominal area, and liquid
fecal discharge. These conditions persisted for 24 h. Necropsy revealed
hemorrhage in the lungs and abnormal distention of stomach and
gastrointestinal tract with gas and fluid. Livers showed a mottled
surface with normal color. The calculated LD50 (oral, rat) of
1,1,2-trichloro-1,2,2-trifluoroethan is 43 g/kg bw.
The acute oral toxicity of the target chemical
1,1,1-trichloro-2,2,2-trifluoroethane is determined by read-across from
an in vivo test (rats) with the source chemical
1,1,2-trichloro-1,2,2-trifluoroethane. The analogue approach is
justified in Section 13 (Assessment Reports_Read-Across, in attachment
CAS_354-58-5_Read-Across.pdf). As a consequence the value for LD50
(oral, rats) of 1,1,1-trichloro-2,2,2-trifluoroethane is 43 g/kg bw.
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