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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-fluoro-4-methyl-1,3,2-dioxaphospholane
- Cas Number:
- 16415-09-1
- Molecular formula:
- C3H6FO2P
- IUPAC Name:
- 2-fluoro-4-methyl-1,3,2-dioxaphospholane
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The solubility test in water solubility test, preliminary stability test, definitive test and limited
test was as follows.
- Test solution of water solubility test (Nominal concentration : 100 mg/L)
- Test solution of stability test (Nominal concentration : 100 mg/L)
- Test solution of definitive test {Nominal concentration : (10, 17, 31, 56, 100) mg/L}
- Test solution of limited test {Nominal concentration : 100 (adjust pH) mg/L}
150 mL (water solubility test, stability test) or 440 mL (definitive test, limited test)
was sampled from the middle layer of each test solution, aliquoted from 10 mL,
mixed with 10 mL methanol, and analyzed (three replicates for each step, four
replicates for definitive test). If additional dilution was required, it was diluted with
methanol/water (50/50, v/v %) and analyzed.
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- (140 – 250) mg CaCO3/L
- Test temperature:
- (18 – 22) ℃, change of water temperature within ±1 ℃
- pH:
- 6.0 – 9.0
- Dissolved oxygen:
- ≧3 mg/L
- Nominal and measured concentrations:
- In the treatment group without pH adjustment, definitive test was performed at the nominal concentration (10, 17, 31, 56, 100) mg/L {average measured concentration: (2.1, 3.1, 4.1, 5.7, 7.7) mg/L}.
In addition, a limit test was performed in the pH-adjusted treatment group {nominal concentration: 100 mg/L (average measured concentration: 7.4 mg/L)}.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Remarks:
- Limited test (after pH adjustment)
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Remarks:
- Limited test (after pH adjustment)
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Remarks:
- Limited test (after pH adjustment)
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Remarks:
- Limited test (after pH adjustment)
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Remarks:
- Definitive test (before pH adjustment)
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Remarks:
- Definitive test (before pH adjustment)
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Remarks:
- Definitive test (before pH adjustment)
- Effect conc.:
- 55.84 mg/L
- 95% CI:
- >= 48.99 - <= 63.65
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Remarks:
- Definitive test (before pH adjustment)
- Effect conc.:
- 70.58 mg/L
- 95% CI:
- >= 65.24 - <= 76.35
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study was conducted to assess the acute toxicity of FCCA-04 under semi-static
system . Determination of EC50 and NOEC were based on nominal concentration and
the measured concentration (Table 6).
9.1 Definitive test (before pH adjustment)
9.1.1 Nominal concentration
- 24 h-EC50 : 70.58 mg/L, [95 % Confidence interval (65.24 – 76.35) mg/L]
- 48 h-EC50 : 55.84 mg/L, [95 % Confidence interval (48.99 – 63.65) mg/L]
- 24 h-NOEC : 31 mg/L
- 48 h-NOEC : 31 mg/L
9.1.2 Measured concentration
- 24 h-EC50 : 6.419 mg/L, [95 % Confidence interval (6.154 – 6.697) mg/L]
- 48 h-EC50 : 5.659 mg/L, [95 % Confidence interval (5.274 – 6.072) mg/L]
- 24 h-NOEC : 4.1 mg/L
- 48 h-NOEC : 4.1 mg/L
9.2 Limited test (after pH adjustment)
9.2.1 Nominal concentration
- 24, 48 h-EC50 : >100 mg/L
- 24, 48-NOEC : 100 mg/L
9.2.2 Measured concentration
- 24, 48 h-EC50 : >7.4 mg/L
- 24, 48-NOEC : 7.4 mg/L
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