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Diss Factsheets
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EC number: 946-945-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP / guideline study without deviations
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- 0, 10, 32, 100, 320 and 1000 mg/L
0, 5, 16 and 50 mg/L of reference item (positive control) - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated.
Immediately before use, the dry weight of the activated sludge was measured again in the inoculum used in the test. The pH was adjusted from 8.4 to 6.9. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- no
- Hardness:
- not measured
- Test temperature:
- Measured in one control:
20 °C at the start of incubation period
19 °C at the end of incubation period.
Monitored in all test media and controls during measurement of respiration rate. - pH:
- Measured in all test media and controls.
Start of test: 7.8 - 8.4 (controls)
8.0 – 8.3 (positive control)
7.9 – 8.1 (treated)
End of test: 9.0 (controls)
8.3 – 9.0 (positive control)
9.0 – 9.1 (treated) - Dissolved oxygen:
- Oxygen
concentration
(mg O2/L)
Start End
7.7 8.3
8.2 8.0
7.9 7.1
8.3 8.2
8.1 8.0
8.3 8.3
8.3 7.7 - Salinity:
- not measured
- Nominal and measured concentrations:
- Nominal: 0, 10, 32, 100, 320 and 1000 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- The results of inoculum controls and positive controls confirmed the suitability of the activated sludge and the method used.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Up to and including the concentration of 1000 mg/L, the test item d-Phenothrin had no significant inhibitory effect (<15 %) on the respiratory rate of activated sludge after the incubation period of three hours. Thus, the 3-hour NOEC (EC15) of d-Phenothrin to activated sludge microorganisms was at least 1000 mg/L or higher, since concentrations in excess were not tested.
The oxygen consumption rates of the two inoculum controls differed by 9.5%, which is within guideline-recommended maximum variation of 15%, and the 3-hour EC50 of reference item 3,5-dichlorophenol (positive control) was calculated to be 23 mg/L, which is within the guideline-recommended range. - Executive summary:
NOEC ≥ 1000 mg/L.
Reference
The inhibitory effect of test item or of the reference item on the respiratory rate (oxygen consumption pr minute) is expressed as a percentage of the mean respiratory rate of the two inoculum controls.
The 3-hour EC50, EC20 and EC80 values for test item and their 95% confidence limits could not be calculated due to the absence of a toxic effect.
The 3-hour EC50 value of reference item 3,5-dichlorophenol was calculated by Probit Analysis.
All test results were based on nominal test item concentrations.
Description of key information
Up to and including the concentration of 1000 mg/L, the test item d-Phenothrin had no significant inhibitory effect (<15 %) on the respiratory rate of activated sludge after the incubation period of three hours. Thus, the 3-hour NOEC (EC15) of d-Phenothrin to activated sludge microorganisms was at least 1000 mg/L or higher, since concentrations in excess were not tested.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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