Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 815-708-2 | CAS number: 83249-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- The sludge was taken from the activation basin of the sewage treatment plant in D-67480 Edenkoben.
Date of collection: 06. Apr. 2018, batch no: 20180406. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 50.9 mg/L
- Based on:
- test mat.
- Remarks:
- Test 1
- Initial conc.:
- 50.9 mg/L
- Based on:
- test mat.
- Remarks:
- Test 2
- Details on study design:
- From each front scrubber flask, 10 samples were taken in order to determine the emitted CO2 (on day 0, 2, 4, 7, 9, 11, 14, 18, 23 and 29). The sample volume was 1 mL. The resulting change in the volume of the front flask was considered in the calculation of emitted CO2.
On day 28, 5 mL HCl 2 M was added to each test flask in order to drive off dissolved CO2. On day 29, samples from both scrubber flasks were taken. - Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 10 d
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 8
- Sampling time:
- 28 d
- Results with reference substance:
- All validity criteria were met. Degradation of the positive control was 61 % after 11 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- • The test item L-Tyrosine, N-acetyl-3,5-diiodo-O-(4-methoxyphenyl)-, ethyl ester is considered as “not readily biodegradable“.
• The degree of biodegradation reached 8 % after 28 days.
• The 10-day-window was not detected.
• Degradation missed 60 % within 28 days, too.
• Therefore, regardless of the 10-day-window, the test item L-Tyrosine, N-acetyl-3,5-diiodo-O-(4-methoxyphenyl)-, ethyl ester is considered as “not ultimately biode-gradable within 28 days”.
• Abiotic degradation was not observed.
Reference
In the following table, the percentage biodegradation is presented:
Table 1 Degradation values in %
Day |
Positive Control 1 |
Positive Control 2 |
Positive Control Mean |
Test 1 |
Test 2 |
Test Mean |
Abiotic Control |
Toxicity Control |
2 |
1.8 |
0.9 |
1.4 |
3.1 |
0.8 |
2.0 |
0.3 |
5.1 |
4 |
6.0 |
10.6 |
8.3 |
3.7 |
1.5 |
2.6 |
1.3 |
23.3 |
7 |
37.1 |
30.8 |
34.0 |
5.3 |
2.1 |
3.7 |
0.9 |
42.3 |
9 |
50.5 |
55.1 |
52.8 |
5.4 |
2.7 |
4.0 |
0.7 |
44.7 |
11 |
58.1 |
63.4 |
60.8 |
4.9 |
3.5 |
4.2 |
0.6 |
46.6 |
14 |
66.3 |
68.0 |
67.1 |
6.1 |
4.5 |
5.3 |
0.5 |
53.5 |
18 |
73.8 |
75.5 |
74.7 |
5.7 |
6.1 |
5.9 |
0.2 |
56.6 |
23 |
76.4 |
75.0 |
75.7 |
7.3 |
6.4 |
6.8 |
-0.3 |
57.5 |
29 |
86.0 |
85.1 |
85.5 |
7.1 |
7.8 |
7.5 |
-0.3 |
58.7 |
As the measured IC values in the abiotic control are very low, measurement uncertainties lead to negative degradation values while in fact no degradation has taken place.
Description of key information
In the study conducted according to OECD 301B only 8 % of the test substance degraded after 28 d. Thus the substance has to be classified as not ultimately biodegradable within 28 days.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.