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Diss Factsheets
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EC number: 700-700-2 | CAS number: 1369492-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Remarks:
- The Daphnia Magna reproduction toxicity study was conducted solely to comply with a non-EU national registration requirement, and has been provided here in accordance with REACH, Article 22(1)e.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- From 01 April 2014 to 27 June 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted under a National quality assurance scheme (HJ/T 155-2004) similar to OECD GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: MEP, P.R. China, the Guidelines for Testing of Chemicals No. 211 "Daphnia magna Reproduction Test"
- Version / remarks:
- Version 2 / 2013
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- 02 October 2012
- GLP compliance:
- no
- Remarks:
- The study was conducted under a National quality assurance scheme (HJ/T 155-2004) similar to OECD GLP.
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0.625, 1.25, 2.5, 5.0 and 10 mg/L were analysed
- Sampling method: Three samples were collected during the definitive test fro analysis (freshly prepared media on 0, 2, 9 and 12 day after exposure, and expired media on 2, 9, 12 and 21 day after exposure. - Vehicle:
- yes
- Remarks:
- water
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Concentration of vehicle in test medium (stock solution): 10 mg/L - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Source: Applying Chemsitry department Pesticide Environmental Evaluation Lab of China agricultural University.
- Age of parental stock: Less than 24 hours old
- Feeding during test: Yes
- Food type: living algal cells
- Amount: 0.1 to 0.2 mg Cells/Daphnia/ day
- Frequency: daily
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 140-250 mg/L (as caCO3)
- Test temperature:
- 20 ± 1°C
- pH:
- 6-9
- Dissolved oxygen:
- Above 3 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0.0625, 1.25, 2.5, 5.0 and 10 mg/L
Measured: 0.062, 0.130, 0.260, 0.523 and 1.06 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass beakers
- Type (delete if not applicable): loosely covered
- Aeration: 24 hours before usage
- Renewal rate of test solution (frequency/flow rate): three times a week
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: demineralized water treated with special softening technics.
OTHER TEST CONDITIONS
- Photoperiod: 16hr light / 8 hr dark
- Light intensity:1000 - 1500 lux
EFFECT PARAMETERS MEASURED :
-pH value, dissolved oxygen, water hardeness, light condition and temperature
TEST CONCENTRATIONS
- Test concentrations: 0.0625, 1.25, 2.5, 5.5 and 10 mg/L - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.062 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- first brood time
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.26 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- total living offspring for each parent
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.26 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- morphology
- Remarks:
- Body length of parent
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.26 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Parental mortality
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.06 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Total dead offspring for each parent
- Details on results:
- - Behavioural abnormalities:
- Observations on body length and weight: significant difference (p<0.01) between control and test concentration of 5.0 mg/L
- Mortality of control: one parent animal died accidentally due to handling error in replicate 10 - Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC for the first brood time was found to be 0.062 mg/L.
- Executive summary:
A reproduction test of the test item was conducted with Daphnia magna over a 21 -day exposure period. The definitive test was conducted with the concentrations of 0.625, 1.25, 2.5, 5 and 10 mg/L (with mean measured concentrations of 0.062, 0.130, 0.260, 0.523 and 1.06 mg/L, concurrently with a blank control group. 10 animals individually held at each test concentration and controls were used.
The test was performed with a semi-static water renewal system.
Total number of living juveniles of each parent, body lenght, parental mortality and total number of dead offspring were calculated. The concentrations were determined in samples of test media by HPLC. The resulst showed that the mean measured concentration of the test item were in the range of 95.4% - 97.1% of the initial measured concnetration.
Reference
Description of key information
A reproduction test of the test item was conducted with Daphnia magna over a 21-day exposure period. The definitive test was conducted with the concentrations of 0.625, 1.25, 2.5, 5 and 10 mg/L (with mean measured concentrations of 0.062, 0.130, 0.260, 0.523 and 1.06 mg/L, concurrently with a blank control group. 10 animals individually held at each test concentration and controls were used.
The test was performed with a semi-static water renewal system.
Total number of living juveniles of each parent, body lenght, parental mortality and total number of dead offspring were calculated. The concentrations were determined in samples of test media by HPLC. The resulst showed that the mean measured concentration of the test item were in the range of 95.4% - 97.1% of the initial measured concnetration.
The NOEC for the first brood time was found to be 0.062 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.062 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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