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EC number: 600-768-2 | CAS number: 106726-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
acute oral LD50 is > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Guideline:
- other: EG-Richtlinie 84/449
- Version / remarks:
- Amtsblatt der Europäischen Gemeinschaften 27, 1984, L251, 96
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Name of test substance in the report: Neodym-Versatat
Appearance: solid
Molecular weight: 657 g/mole
Molecular formula: C30H57NdO6 - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: about 9 weeks (males) to 14 weeks (females)
- Weight at study initiation: mean 171 g (males) and 176 g (females)
- Fasting period before study: 16 hours
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 60% +/- 10%
- Photoperiod (hrs dark / hrs light): 12 hours
IN-LIFE DATES: From: 13.08.1985 To: 02.09.1985 - Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10/20 mL - Doses:
- 1000 mg/kg bw and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- higher doses were not applicable due to the limited solublilty of the test item in the vehicle
Observations:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily for clinical signs; body weighing before treatment, one week and two weeks after treatment
- Necropsy of survivors performed: yes - Sex:
- male
- Dose descriptor:
- LD50 cut-off
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- males: on male died on day 8 after application of 1000 mg/kg bw; two males died within the first 2 days after application of 2000 mg/kg bw
females: no mortality - Clinical signs:
- other: males: both doses led to a reduced general condition and piloerection females: 1000 mg/kg bw were well tolerated; 2000 mg/kg bw led to a reduded general condition
- Gross pathology:
- in the unscheduled deaths effects slight reddening was seen to the mucous membrane of the stomach and intestine
- Executive summary:
In an acute oral toxicity study performed in 1985 the test item was given by oral gavage to 5 Wistar rats/sex in doses of 1000 and 2000 mg/kg bw. As vehicle DMSO was used that was applied in amounts of 10 and 20 mL/kg bw, respectively. Mortality was observed only in males at 1000 (1 male) and 2000 mg/kg bw (2 males). A reduced general condition was seen in all treated males and in females of the 2000 mg/kg bw group. The LD50 was determined in this study with >2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study performed in 1985 the test item was given by oral gavage to 5 Wistar rats/sex in doses of 1000 and 2000 mg/kg bw. As vehicle DMSO was used that was applied in amounts of 10 and 20 mL/kg bw, respectively. Mortality was observed only in males at 1000 (1 male) and 2000 mg/kg bw (2 males). A reduced general condition was seen in all treated males and in females of the 2000 mg/kg bw group. The LD50 was determined in this study with >2000 mg/kg bw.
Justification for classification or non-classification
Based on the available studies no classification is warranted for acute oral toxicity. No studies are available for acute dermal and acute inhalation toxicity.
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