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EC number: 469-500-8 | CAS number: 857035-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 04 December 2006 to 29 June 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: compliant to GLP and testing guideline; adequate coherence between data, comments and conclusions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): R0054002C, synonym IMEXINE OBH
- Physical state: beige to yellow powder
- Purity: 99.7%
- Impurities (identity and concentrations): not indicated
- Purity test date: 20 July 2006
- Lot/batch No.: R0054002C 013 L 001, synonym 0604070001
- Expiration date of the lot/batch: 01 August 2007
- Stability under test conditions: not indicated
- Storage condition of test material: at room temperature and under nitrogen gas
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken from the limit test solution (1000 mg/L) at the beginning of the test, before and after each solution change and at the end of the test.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- zebra fish (Danio rerio) a species commonly used in Europe for aquatic toxicity testing and recommended in OECD and EEC guidelines.
Origin: HB Développement, Saint Forgeux, France
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 147 and 149 mg/L as CaCO3
- Test temperature:
- Between 21.4°C and 22.2°C
- pH:
- pH: 6.17 to 8.46
- Dissolved oxygen:
- 8.1 to 9.2 mg/L (≥ 60% of the air saturation value)
- Salinity:
- Not measured
- Nominal and measured concentrations:
- limit test: 1000 mg/L nominal corresponding to 659 mg/L expressed as geometric mean of measured concentrations
range finding test: 100 and 316 mg/L nominal (no measurement) - Details on test conditions:
- Test solutions were changed every 24 over the 96-hour test period.
Test water: filtered and dechlorinated potable water which is then softened by a Permo® water softening system. Half of the water passes directly into a holding tank attached to the flow-through system while the remaining half passes through a deionizer producing ultra-pure water which is then fed into the holding tank. This results in a 1:1 dilution of potable dechlorinated:deionized water giving a supply of the desirable hardness. The pH of this medium is between 6.0 and 8.5 (generally in the range 7.5 - 8.0) and the total hardness is between 10 and 250 mg/L as CaCO3 (generally in the range 130 - 170 mg/L as CaCO3).
Temperature: between 21°C and 25°C and not ranging by more than ± 1°C throughout the test.
Light/dark cycle: 16/8 hours.
Duration of test: 96 hours.
Loading: fish mean weight was 2.32 g for the test, based on a sample of ten animals removed at random from the acclimation tank just before the test.This corresponded to a loading of 0.81 g/L during the study.
Length: the animals ranged from 25 to 30 mm long (based on a measurement of a sample of 31 fishes used in the test).
pH in test item solutions: between 6 ± 0.2 and 9 ± 0.2 after pH adjustment when relevant (i.e. < 5.8 or >9.2).
Forced aeration: continuously used during the test in all solutions. Dilution water was aerated prior to addition of the test item.
Oxygen concentrations: ≥ 60% of the air saturation value at that temperature. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 659 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 659 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- dissolved
- Basis for effect:
- other: mortalilty and sub-lethal effects
- Details on results:
- Neither mortality nor sub-lethal effects were noted at any of the concentrations tested (100, 316 and 1000 mg/L nominal).
- Results with reference substance (positive control):
- LC50 24 h (potassium dichromate) = 233 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a 96-hour semi-static acute toxicity test with Danio rerio, the LC50 of IMEXINE OBH was > 659 mg/L (geometric mean of measured concentrations).
The No Observed Effect Concentration (NOEC) was ≥ 659 mg/L (geometric mean of measured concentrations).
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