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Diss Factsheets
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EC number: 415-070-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- Pow
- Partition coefficient:
- < 0
- Temp.:
- 20 °C
- Remarks on result:
- other: as not in applicability range of flask-method, interpreted as estimated value
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -5.9
- Temp.:
- 20 °C
- Remarks on result:
- other: as not in applicability range of flask-method, interpreted as estimated value
- Conclusions:
- The partition coefficient (n-octanol/water) of test item was estimated to be < 1.2 * 10^-6 (log Pow < -5.9), using the flask-shaking method.
- Executive summary:
In order to evaluate the partition coefficient of the test substance between n-octanol and water, a study was conducted using flask-shaking method, according to the method A. 8 of EEC-Directive 92/69 EEC. The partition coefficient (n-octanol/water) of test item was estimated to be < 1.2 * 10-6, as a mean value of both measurements. Because this value was not within the applicability range of the flask-shaking method, the main study was not performed and the result has to be interpreted as an estimated value.
Reference
During the preliminary test 1, the solubility of the test substance in n-octanol was determined to be 10 x 10-3 g/l. No significant differences were observed between the concentrations analysed after the second and third centrifugation step. The available water solubility of test item was 400 g/l.
Hence, the partition coefficient Pow was estimated to be 2.5 x 10-5 (log Pow = -4.6).
During preliminary test 2, it was observed that the n-octanol phase was coloured red/brown. The colour of the test substance is black/blue. During preliminary test 1, the n-octanol was coloured blue. It was assumed that the red/brown colour of the n-octanol phase derived from an impurity from the test substance with a higher log Pow than the main component. This impurity showed no absorption at the detection wavelength used for the HPLC analysis and did not interfere with the analyses.
As the mean value of both measurements was not within the applicability range of the flask-shaking method, the main study was not performed and the result has to be interpreted as an estimated value.
Description of key information
Log Pow < -5.9 (Pow < 1.2 x 10-6) at 20 °C
Key value for chemical safety assessment
Additional information
In order to evaluate the partition coefficient of the test substance between n-octanol and water, a study was conducted according to the method A. 8 of EEC-Directive 92/69 EEC.
The partition coefficient (n-octanol/water) of test item was estimated to be < 1.2 * 10-6, using the flask-shaking method (log Pow < -5.9).
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