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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 296-120-8 | CAS number: 92257-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 30
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 40
Additional information
Due to the complex composition of this substance 6 representative constituents (A-G) were used to assess the potential ADME properties using
ADMET predictor (v7.2, Simulations Plus Inc, Lancaster, CA, USA),andGastroPlus (v9.0, Simulations Plus Inc, Lancaster, CA, USA).
The model used an exposure of 1 mg/kg (oral, dermal, inhalation) or 5 mg/kg (dermal) in a 30-year old human (70 kg), and predicted the fractional absorption (Fa%), bioavailability (F%), and maximum plasma concentration (Cmax) values for oral, dermal, and inhalation exposures to components A-G.
Overall, the predicted Cmaxvalues from oral or inhalation exposure for each component are higher than from dermal exposure; at the dermal exposure level of 1mg/kg or 5 mg/kg, the predicted Cmaxvalues for each component are much lower than the corresponding Cmaxvalues at 1 mg/kg oral exposure level, indicating that much higher than 5 mg/kg dermal exposure level of each component will be needed to produce the corresponding oral Cmaxlevel. Similar human protein binding (approx 99%) and Vd values (between 0.7 and 1.15 l/Kg) are predicted for all components.
Taking the predicted bioavailability for each of the representative structures along with the amount of each structure likely to be present in the registered substance it was possible to estimate the approximate amount of the overal substance that would be bioavailable via each route. These figures are reported above.
Based on the metabolism prediction by ADMET predictor, all components can be metabolized to hydroxylated metabolites (by human CYP 1A2 and CYP 3A4). Also according to the metabolism information of some Azo dyes, all components can be metabolized to the individual aromatic amine metabolites (by Azo reduction in human intestine ad to a limited extent on the skin).The formed metabolites can also be further metabolized to water soluble metabolites (such as glucuronides and sulfates), which will be mainly excreted into urine and feces.
On the basis of low volume of distribution, and predicted metabolism and excretion of all components, it can be predicted that this substance is not likely to bioaccumulate in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.