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EC number: 284-903-7 | CAS number: 84989-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- expert statement
- Type of information:
- other: assessment of available information
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400347), but data are currently available fromin vivoandin vitrotoxicology studies.
The substance, WS400347, is a UVCB substance, calcium salts ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs. The substance has low water solubility (172 mg/l) but it dissociates in water to a sufficient extent to exhibit surface activity. Themolecular weight of the acids amounts to approx. 340 Da (C12 alkyl-derivative). Based on the fact that the substance has surface activity there is no true value for lipophilicity.
It is expected (and was confirmed in bridging studies) that the salt dissociates in aqueous environments. Accordingly, exposure of man and the environment will be to calcium andbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
Calcium is a major element in our daily diet und thus of low toxicity. Therefore, any adverse effects of WS400347 will be based on toxic properties ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
After oral exposure to WS400347 absorption ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivsand systemic distribution is to be expected based on the low molecular weight. In repeat dose feeding studies performed with sodium salts of different linear alkylbenzenesulfonic acids,that were used as read-across source substance, some effects in liver and kidneys were observed at high doses indicating systemic distribution. In acute oral toxicity studies performed in rats with the read-across source substances the LD50 ranged from doses of approx. 1000 to 1600 mg/kg body weight.
Systemic availability of WS400347 after dermal application is expected to be low based on absence of acute dermal toxicity in a study performed with a read-across source substance. However, based on surface activity of WS400347 and based on skin irritation observed with sodium salts of linear alkylbenzenesulfonic acids skin penetration may be enhanced after irritation.
Availability of WS400347 under a vapour state can be excluded, because of its very low vapour pressure (10^-17 Pa, calculated).
There is no information on metabolism and excretion of WS400347.
Based on the available information the bioaccumulation of WS400347 cannot be assessed.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
Additional information
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400347), but data are currently available fromin vivoandin vitrotoxicology studies.
The substance, WS400347, is a UVCB substance, calcium salts ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs. The substance has low water solubility (172 mg/l) but it dissociates in water to a sufficient extent to exhibit surface activity. Themolecular weight of the acids amounts to approx. 340 Da (C12 alkyl-derivative). Based on the fact that the substance has surface activity there is no true value for lipophilicity.
It is expected (and was confirmed in bridging studies) that the salt dissociates in aqueous environments. Accordingly, exposure of man and the environment will be to calcium andbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
Calcium is a major element in our daily diet und thus of low toxicity. Therefore, any adverse effects of WS400347 will be based on toxic properties ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivs.
After oral exposure to WS400347 absorption ofbenzenesulfonic acid, 4-sec-C10-13-alkyl derivsand systemic distribution is to be expected based on the low molecular weight. In repeat dose feeding studies performed with sodium salts of different linear alkylbenzenesulfonic acids,that were used as read-across source substance, some effects in liver and kidneys were observed at high doses indicating systemic distribution. In acute oral toxicity studies performed in rats with the read-across source substances the LD50 ranged from doses of approx. 1000 to 1600 mg/kg body weight.
Systemic availability of WS400347 after dermal application is expected to be low based on absence of acute dermal toxicity in a study performed with a read-across source substance. However, based on surface activity of WS400347 and based on skin irritation observed with sodium salts of linear alkylbenzenesulfonic acids skin penetration may be enhanced after irritation.
Availability of WS400347 under a vapour state can be excluded, because of its very low vapour pressure (10^-17 Pa, calculated).
There is no information on metabolism and excretion of WS400347.
Based on the available information the bioaccumulation of WS400347 cannot be assessed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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