Registration Dossier
Registration Dossier
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EC number: 255-460-7 | CAS number: 41611-76-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- < 0 g/L
- Temp.:
- 20 °C
- pH:
- 6.2 - 6.8
- Remarks on result:
- other: Mean value of two columns
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L) not detectable < 0.00002 g/l
The water solubility was not detectable with a value lower than 0.00002 g/l at 20 °C. - Executive summary:
The determination of the water solubility by the column elution method was based on the OECD guideline for testing of chemicals No: 105 “Water solubility“ (adopted 27thJuly 1995). The water solubility of the test item at 20 °C was not detectable < 0.00002 g/l.
Reference
Nineteen fractions were collected from column 1 and ten fractions from column 2. Ten data points including the five fractions with constant concentrations, were used for the determination of the water solubility. For each fraction 10 mL were collected. The quantification was done by external standardization. Using the results of the calibration chromatograms a calibration curve was calculated by linear regression.
Description of key information
The water solubility of the test item was not detectable with a value lower than 0.00002 g/l at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0 g/L
- at the temperature of:
- 20 °C
Additional information
- "should read: < 0.00002 g/L"
- Mean value of both columns: not detectable
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