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EC number: 241-698-9 | CAS number: 17696-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-03-06 to 2018-12-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- CAS No.: 17696-62-7
Batch: 018964K19K
Expiry date: 02 August 2018
Purity: 99.1%
Appearance: White powder
Storage: Room temperature - Key result
- Water solubility:
- < 0.05 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20 °C
- pH:
- ca. 6.5
- Remarks on result:
- other: LOQ of analytical method: 0.05 mg/L
- Conclusions:
- The water solubility of the test item was lower than 0.05 mg/L (< LOQ) at 20 °C and a pH of approx. 6.5.
- Executive summary:
The water solubility of the test item was determined according to OECD test guideline 105 using the column elution method. The water solubility of the test item was lower than 0.05 mg/L (< LOQ) at 20 °C and a pH of approx. 6.5.
Reference
Preliminary test:
Tables 1 and 2 summarize the results of the preliminary test (test temperature 21.0 °C).
Table 1: Results of preliminar test (1 part)
Amount of test item / g |
0.10 |
|||||
Amount of water / mL |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
Approx. solubility / g/L |
> 1,000 |
1,000 to 200 |
200 to 100 |
10 to 50 |
50 to 10 |
10 to 1 |
Results |
Not soluble |
Not soluble |
Not soluble |
Not soluble |
Not soluble |
Not soluble |
Table 2: Results of preliminary test (part 2)
Amount of test item / g |
0.01 |
0.005 |
Amount of water / mL |
100 |
5,000 |
Approx. solubility / g/L |
1 to 0.1 |
0.1 to 0.001 |
Result |
Not soluble |
Not soluble |
Taking the visual observations into account, the preliminary test shows that the solubility of the test item was lower than 0.001 g/L. Thus the column elution method was selected for the main test.
Validation criteria:
In accordance with results from the analytical method validation, all acceptance criteria were satisfied. The applied method is consistent with the requirements of the validation for the quantitative analysis of the test item in the solutions.
Main test: Column elution method:
The results of the hydrosolubility determination are indicated in Table 3 and Table 4.
Table 3: Results of the main test (flow rate 25 mL/h)
Sample |
Final results (mg/L) |
pH |
1 (T: 30 minutes) |
< 0.05 |
Between 6 and 7 |
2 (T: 1h02min) |
< 0.05 |
Between 6 and 7 |
3 (T:1h36min) |
< 0.05 |
Between 6 and 7 |
4 (T: 2h10min) |
< 0.05 |
Between 6 and 7 |
5 (T: 2h44min) |
< 0.05 |
Between 6 and 7 |
6 (T: 3h17min) |
< 0.05 |
Between 6 and 7 |
Average (mg/L) |
< 0.05
|
|
Standard deviation (mg/L) |
/ |
|
Relative standard deviation of repeatability |
/ |
Table 4: Results of the main test (flow rate 12.5 mL/h)
Sample |
Final results (mg/L) |
pH |
1 (T: 30 minutes) |
< 0.05 |
Between 6 and 7 |
2 (T: 1h01min) |
< 0.05 |
Between 6 and 7 |
3 (T:1h34min) |
< 0.05 |
Between 6 and 7 |
4 (T: 2h06min) |
< 0.05 |
Between 6 and 7 |
5 (T: 2h38min) |
< 0.05 |
Between 6 and 7 |
6 (T: 3h10min) |
< 0.05 |
Between 6 and 7 |
Average (mg/L) |
< 0.05
|
|
Standard deviation (mg/L) |
/ |
|
Relative standard deviation of repeatability |
/ |
The analysis of the test item obtained at elution flow rates of 12.5 and 25 mL/h indicated a solubility in water which is lower than 0.05 mg/L (< LOQ).
Description of key information
The water solubility of the test item was determined according to OECD test guideline 105 using the column elution method. The water solubility of the test item was lower than 0.05 mg/L (< LOQ) at 20 °C and a pH of approx. 6.5.
Key value for chemical safety assessment
Additional information
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