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Diss Factsheets
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EC number: 241-677-4 | CAS number: 17689-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key oral gavage study conducted to the now deleted OECD 401 and to GLP (Huntingdon Life Sciences, 2000) the LD50 for triacetoxyethylsilane was 1460 mg/kg bw in rats. Clinical signs and macroscopic findings appeared to be related to the corrosive properties of the test substance on the stomach.
There are no dermal or inhalation studies available, and it is not scientifically feasible to conduct new tests as the test substance has corrosive properties.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 460 mg/kg bw
Additional information
There are two reliable oral studies for the acute toxicity endpoint. The most recent and most reliable of the two studies was selected as the key study. The supporting study (Bayer AG, 1980), gave a higher LD50 value of 2400 mg/kg bw (dose given in ml/kg, converted using a relative density of 1.14).
Since one mole (234 g) of silane produces three moles (180 g) of acetic acid, it is expected that the LD50 for the silane would be (234/180)*LD50 of acetic acid. So, if the LD50 for the acid is 1083 mg/kg bw (as reported in SIAR, 2006), then the LD50 of the silane would be ca.1410 mg/kg bw. This assumes that the silanol does not contribute to the intrinsic toxicity of the substance.
The calculated value is in good agreement with the reported LD50of ethyltriacetoxysilane of 1460 mg/kg bw (rat), confirming the above assumption.
Justification for classification or non-classification
Based on the available acute oral toxicity data, triacetoxyethylsilane is classified 'Acute Toxic 4 (oral)' with the hazard statement 'H302: Harmful if swallowed' according to Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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