Octanoic acid, compound with octylamine (1:1)

Endpoint summary

Description of key information

skin irritation/corrosion:
- rabbit (dodecylamine): corrosive
- rabbit (coco alkylamines): highly corrosive
- rabbit (coco alkylamines): corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

There is no experimental data on skin/eye irritation/corrosion for caprylamine caprylate. The skin irritation/corrosion potential of caprylamine caprylate is derived from the available data of dodecylamine and coco (source chemicals).

Clear skin corrosive effects was observed in studies with both dodecylamine and coco alkylamines. Therefore, the target substance caprylamine caprylate is also considered as corrosive to skin.

According to EU regulation 1907/2006, Annex VII, column 2, the study regarding eye irritation needs not to be conducted since the substance is classified as corrosive to the skin.

The target chemical caprylamine caprylate is an ionic compound that results from the neutralization reaction of the compounds of octanoic acid and octylamine. In aqueous solution or in a biological fluid, it could be dissociate as octanoic acid and octylamine. Therefore, the toxicity toxicological profile of the target chemical should be comparable to that of octylamine and octanoic acid. Based on the basic concept of “chain length category”, the use of toxicity data of other fatty amines for read-across purpose to octylamine and the target chemical is justified. The dissociated product of the target chemical – octylamine and the source chemicals of dodecylamine and coco alkylamines belong to the homologues series of fatty amines and form a “chain length category”, where there is an incremental increase in the number of CH2 units. Therefore, it can be reasonably assumed that octylamine and other fatty amines (dodecylamine and coco alkylamines) share the same toxic mode of action.

All the chemicals are assessed using the rule based expert system DEREK Nexus based on their chemical structures. The assessment results are identical for the target chemical octylamine, dodecylamine and coco alkylamines: all the chemicals are predicted as negative for mutagenicity in bacteria. No toxicity potential or structure alert is identified.

With regard to the endpoint of skin irritation/corrosion, corrosive effect was identified for the source chemicals of octylamine, dodecylamine and coco alkylamines. The target chemicals is also considered as corrosive to skin (Cat 1A) based on the analogue approach. For this endpoint, the analogue approach is also justified considering the “worst case” scenario.

Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

Based on the available data the subatance is classified as Category 1A for skin irritation/corrosion, according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).