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EC number: 234-585-0 | CAS number: 12013-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- from 16th march 2012 to 16th April 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in compliance with international recognized guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tin dioxide
- EC Number:
- 242-159-0
- EC Name:
- Tin dioxide
- Cas Number:
- 18282-10-5
- IUPAC Name:
- 18282-10-5
- Details on test material:
- Test item ( as cited in the report): tin dioxide
Lot. n: W0167
Active ingredient: tin dioxide
CAS n. 18282-10-5
Content of active ingredient (analysed): >99%
Appaerance: white powder
Storage conditions: ambient temp., dark, dry
Expiry date: 07 February 2013
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- The sludge was used one day after collection. it was settled for about 10 minutes and the uppor layer with finer solids decanted. before starting the test, it was washed three times with chlorine free tap water by centrifugation (10 min at 3000 rpm). After centrifuging, the supernatant was decanted and discarded and the sludge was resuspended in chlorine free tap water. this procedure was repeated twice.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test mixtures containing water, synthetic wastewater and the test item were prepared to obtain different nominal concentrations of the test item. All test item concentrations, 1000, 100 and 10 mg/L were weighted directly into the test vessels.
The test items 1000 and 100 mg/L were performed with a final volume of 500 mL whereas 10 mg/L test item concentration was performed with a final volume of 1000 ml.
the abiotic control was prepared with the highest test item concentration water and synthetic wastewater.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Activated sludge from the minucipal wastewater treatment plant of Pforzheim, Germany, collected from the aeration tank, was used as the inocolum for the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
- Post exposure observation period:
- no data
Test conditions
- Hardness:
- no data, composition according to the guideline.
- Test temperature:
- 17.8 - 21.7°C ( measured during O2 determination at 30 min and 3 h after start of respiration)
- pH:
- 7.38 - 8.13
- Dissolved oxygen:
- no data, the study determines the consumption of oxygen see "details on test condistions"
- Salinity:
- no data, composition according to the guideline.
- Nominal and measured concentrations:
- A range finding test was performed with concentrations from 10, 100 and 1000 mg/L in a limit test design. The highest concentration of 1000 mg/L was tested in three replicates whereas 10 and 100 mg/L were tested in one replicate.
Since no toxic effect were observed in the range-finding test which was performed in a limit test design, no further experimental testing was necessary - Details on test conditions:
- Synthetic wastewater and the corresponding test solutions wre filled up with water to a final volume of approximately 250 ml for the test item concentrations 100 and 1000 mg/L and up to 500 ml for the 10 mg/l test item concentration.
The reference assay with different concentrations (e.g. 2,5,10 and 25 mg/l) was set up in the same way as the test item concentration 1000 and 100 mg/L. The abiotic control was performed without microbial inocolum but with the highest test item concentration and filled up with water to a final volume of 250 ml. The blank control was set up in the same way as the test item concentrations 1000 and 100 mg/l but without test item.
Aeration was performed for some minutes to saturate the solution with O2 above 60-70%. At T0= h 250ml of microbial inocolum were added except the 10 mg/l test item concentration which was inoculated with 500 ml. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorphenol
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- The coefficient of variation of the control for total oxygen uptake were 8% and 3% after 30 min and 3h respectively and did not exceed 30%.
- Results with reference substance (positive control):
- four concentration of 3,5-dichlorophenol as toxic reference were also tested to demonstrate the sensitivity of the test system.
The EC50 for 3,5-Dichlorophenol (DCP) was determined to be in a range of 10 to 25 mg/L after 30 min and 5 mg/L after 3 hours. These values were whithin the recommended range of 2 to 25 mg/L. - Reported statistics and error estimates:
- The NOAEC was determined using the t-Test pooled. P-values below 0.05 showed statistically significant differences to the control. A test for normality was performed.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect of the test item on microrganisms of an aerobic treatment plant was tested using the activated sludge respiration test.
The test item tin dioxide had no toxic effects on the oxygen uptake at the highest concentration tested (1000 mg/l). Hence, the EC50 of tin dioxide is > 1000 mg/l and the NOAEC is 1000 mg/l.
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