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EC number: 233-588-4 | CAS number: 10250-45-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 September 2018 to 22 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- other: at 20°C by the slowstirring flask method
- Key result
- Water solubility:
- 0.032 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 48 - <= 96 h
- Temp.:
- 20 °C
- pH:
- >= 8.7 - <= 8.9
- Details on results:
- Preliminary Test
After one centrifugation step the content of test item dissolved in the water sample was 0.00891 g/L. After two centrifugation steps no test item was detected due to the volatility of the test item. Therefore, the main study was based on the calculated water solubility of 17 mg/L.
Main Study
The analysed test item concentrations during the first main study were 0.0105, 0.00800 and 0.0194 g/L after 24, 48 and 72 hours respectively. The high maximum difference of 83% was possibly caused by loss of test item due to its volatility during the sample dilution step. The main study was repeated eliminating the dilution step by extending the calibration curve to a higher concentration level of 30 mg/L. Also a 96-hour sample was included during the second main study to obtain more information about a possible trend.
The 24-hour measurement was significantly higher than the 48-, 72- and 96- hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48-, 72- and 96-hour measurements.
No test item was detected in the pretreated sample from the blank water mixture. - Conclusions:
- Under the conditions of this study, the water solubility of the test material at 20 °C was 0.032 g/L.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840, under GLP conditions.
The slow stirring flask method was applied for the determination of the water solubility of the test material. The pH of the aqueous samples was between 8.7 and 8.9.
Under the conditions of this study, the water solubility of the test material at 20 °C was 0.032 g/L.
Reference
Water Solubility of the Test Material
Stirring Time (hours) |
Analysed Concentration (g/L) |
Mean (g/L) |
Maximum Difference (%) |
pH |
48 |
0.034 |
0.032 |
12 |
8.9 |
72 |
0.031 |
8.7 |
||
96 |
0.032 |
8.7 |
An additional data point of 24 hours was initially recorded but was significantly higher (analysed concentration = 0.063 g/L) than the 48-, 72- and 96- hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48-, 72- and 96-hour measurements.
Description of key information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840, under GLP conditions.
The slow stirring flask method was applied for the determination of the water solubility of the test material. The pH of the aqueous samples was between 8.7 and 8.9.
Under the conditions of this study, the water solubility of the test material at 20 °C was 0.032 g/L.
Key value for chemical safety assessment
- Water solubility:
- 0.032 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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