Registration Dossier
Registration Dossier
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EC number: 232-401-3 | CAS number: 8016-11-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Studies of acute oral toxicity and acute dermal toxicity are available. A study of acute inhalation toxicity is not required, on exposure grounds.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- January 22, 1981 - February 4, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- May not be GLP compliant. Control animals were not mentioned. As no signs of toxicity were seen in 10 rats it is safe to assume that Soybean oil, epoxidised is not toxic therefore this deviation should not be an issue. Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Justification for type of information:
- Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Although pre-dating the formal guideline, the study was conducted in general concordance with a limit test as described in OECD method 401. The vehicle selected was described as PAG with no elucidation. It is assumed that it was polyethylene glycol (PEG), which was comonly used for acute gavage administration and this would explain the absence of a separate vehicle control group.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF) Strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Healthy random bred rats of the Tif:RAIf (SPF) strain , which were raised on the Ciba-Geigy Ltd, Basle, laboratory premises
- Age at study initiation: 7 to 8 weeks old
- Weight at study initiation: male mean = 185g; female mean = 174g
- Fasting period before study: rats were fasted overnight prior to treatment
- Housing: in groups of 5 in Macrolan cages
- Diet (e.g. ad libitum): NAFAG, Gossau SG
- Water (e.g. ad libitum): potable water source not specified in report
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C
- Humidity (%): 55 ± 10 %
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 14/10
IN-LIFE DATES: From: 22 January 1981 To: 4 February 1981- Route of administration:
- oral: gavage
- Vehicle:
- other: PAG. Assumed to be PEG = polyethylene glycol
- Details on oral exposure:
- The report indicates PAG was used as a vehicle (it is assumed this is a typographical error and that PEG, polyethylene glycol was actually used).
The test material was dispensed at 20 ml/kg bw.
Animals were fasted overnight and treated by single oral intubation. - Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 animals per group
- Control animals:
- not specified
- Details on study design:
- Bodyweights were recorded immediately prior to dosing and after 7 and 14 days. Physical condition and mortality were monitored throughout the observation period.
- Statistics:
- LD50 including 95 % confidence limits are calculated by the logit model.
- Preliminary study:
- Not relevant
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No confidence intervals or median lethal dose calculated for the 5g/kg bw limit test
- Mortality:
- None of the rats died
- Clinical signs:
- See Table 2 below
Evidence of slight dyspnoea, slightly ruffled fur, slight diarrhoea and a slightly curved body position were noted primarily on Day 1 (1-24 h after administration). Some cases of ruffled fur and curved body position persisted on days 2 to 4. - Body weight:
- See Table 1 below
- Gross pathology:
- No gross organ changes were observed
- Other findings:
- No further information supplied
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of TK 11'278 in rats of both sexes observed over a period of 14 days is greater than 5000 mg/kg. The test material is therefore practically non toxic to the rat by this route of administration. According to Regulation (EC) No. 1272/2008, no classification is warranted.
- Executive summary:
The acute oral LD50 of TK 11'278 in rats of both sexes observed over a period of 14 days is greater than 5000 mg/kg. The test material is therefore practically non toxic to the rat by this route of administration. According to Regulation (EC) No. 1272/2008, no classification is warranted.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Very little information provided on the materials and methods of the study. Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Justification for type of information:
- Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Not stated - the tabulated results indicate a determination of the median lethal dose which suggests a standard acute toxicity method e.g. OECD Method 401
- GLP compliance:
- no
- Test type:
- other: Rangefinding test determining oral LD50 in rats in terms of mL/kg and dermal toxicity in rabbits in mL/kg bw among other acute endpoints
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No further data supplied for range-finding studies
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- This report does not provide details on oral exposure.
- Doses:
- Dose levels are not specified for the oral range finding test
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- No details given in publication for the study design used to determine acute median lethal dose. More information supplied for other testing referenced in this paper - see cross references above. The design appears to be a reasonably conventional OECD 401 type test.
- Statistics:
- No data supplied
- Preliminary study:
- No data supplied
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 22.5 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 14 - 36
- Mortality:
- No data supplied. Median lethal dose determined as 22.5 ml/kg bw
- Clinical signs:
- No data supplied
- Body weight:
- No data supplied
- Gross pathology:
- No data supplied
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A range of toxicity and irritation results for various epoxy monomers is documented in this report. No consistent correlations with structure are evident.
The median lethal oral dose was calculated to be 22.5 ml/kg bw for rats - Executive summary:
Carcinogenic and acute toxicity potential of the test material was assayed.
Irritation
The irritation result given is provided for irritation on an uncovered rabbit belly and was given a score of 2.
Toxicity
A wide range of toxicity and irritation of epoxy monomers is documented in this report. No consistent correlations with structure are evident.
Carcinogenicity
The test was successfully completed. The test material was not considered to be tumorigenic to the mouse skin.
Sebaceous Gland Suppression
The mena number of sebaceous glands per square centimeter of skin of epoxide-dosed mice has been graded against that of the control mice. As the material was applied undiluted, it was compared to a distilled water control group. This substance was tested by both the sebaceous gland (S.G.T.) and the lifetime tests (L.T.T.). The L.T.T. was negative, the tumour and the cancer index were both 0.0. It was given a S.G.T. grade of 0.
The authors of this report have indicated that the S.G.T., based on the data in this report, is merely a crude screen to indicate potential L.T.T. tumorigens, not a test to be used to from definite positive or negative conclusions concerning tumorigenesis.
Sensitisation:
Sensitisation of guinea pigs was determined by a technique consisting of eight intracutaneous injections (three per week on alternate days) of 0.1 mL of the diluted epoxy materials. A three week incubation period was followed by a challenge dose, and examinations for possible sensitisation reactions were made 24 and 48 hours thereafter.
It was concluded that the test material was not sensitising.
Referenceopen allclose all
Table 1: Bodyweight change
|
Dose – 5000 mg/kg |
|
Mean (g) |
Standard Deviation (g) |
|
Day 1 (Male) |
185 |
1.8 |
Day 1 (Female) |
174 |
1.2 |
Day 7 (Male) |
236 |
5.1 |
Day 7 (Female) |
186 |
1.8 |
Day 14 (Male) |
289 |
5.7 |
Day 14 (Female) |
215 |
2.9 |
Table 2: Clinical Signs
Dose – 5000 mg/kg |
||||||||||||||||||
Signs and Symptoms |
Hours |
Days |
||||||||||||||||
1 |
2 |
3 |
5 |
24 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
|
Sedation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Dyspnoea |
+ |
+ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Dacryorrhoea |
|
|
|
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|
|
|
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|
|
|
|
|
|
|
|
|
|
Chromodacryorrhoea |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Rinorrhoea |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Epistaxis |
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exophthalmos |
|
|
|
|
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|
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|
|
|
|
Salivation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ruffled fur |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
|
|
|
|
|
|
|
|
|
|
Pallor |
|
|
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Cyanosis |
|
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|
|
|
|
|
Diarrhoea |
|
+ |
+ |
+ |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Body Position (ventral) |
|
|
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|
|
Body Position (lateral) |
|
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|
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|
|
|
|
|
Body Position (curved) |
+ |
+ |
+ |
+ |
+ |
+ |
|
|
|
|
|
|
|
|
|
|
|
|
Ataxia |
|
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Trismus |
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Tremor |
|
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Tonic clonic muscle spasms |
|
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Convulsions |
|
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|
|
+ = slight
Toxicity
A wide range of toxicity and irritation of epoxy monomers is documented in this report. No consistent correlations with structure are evident.
Range-finding results are reported for a number of acute investigations including oral, dermal and inhalation toxicity, skin and eye irritancy and skin sensitisation potential.
The median lethal oral gavage dose in rats was calculated to be 22.5 mL/kg bw.
Carcinogenicity
The test was successfully completed. The test material was not considered to be tumorigenic to the mouse skin.
Sebaceous Gland Suppression
The mean number of sebaceous glands per square centimeter of skin of epoxide-dosed mice has been graded against that of the control mice. As the material was applied undiluted, it was compared to a distilled water control group. This substance was tested by both the sebaceous gland (S.G.T.) and the lifetime tests (L.T.T.). The L.T.T. was negative, the tumour and the cancer index were both 0.0. It was given a S.G.T. grade of 0.
The authors of this report have indicated that the S.G.T., based on the data in this report, is merely a crude screen to indicate potential L.T.T. tumorigens, not a test to be used to from definite positive or negative conclusions concerning tumorigenesis.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Very little information provided on the materials and methods of the study. Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Justification for type of information:
- Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Not stated - the tabulated results indicate a determination of the median lethal dose which suggests a standard acute toxicity method e.g. OECD Method 403
- GLP compliance:
- no
- Test type:
- other: Rangefinding test determining oral LD50 in rats in terms of mL/kg and dermal toxicity in rabbits in mL/kg bw among other acute endpoints
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No further data supplied for range-finding studies
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- This report does not provide details on dermal exposure, other than stating single skin application to rabbits.
- Duration of exposure:
- Not specified in publication
- Doses:
- Reported results indicates the maximum applied dose was 20 ml/kg bw.
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- No details given in publication for the study design used to determine acute median lethal dose. More information supplied for other testing referenced in this paper - see cross references above. The design appears to be a reasonably conventional OECD 403 type test.
- Statistics:
- No data supplied
- Preliminary study:
- No data supplied
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No data supplied. Median lethal dermal dose determined as >20 ml/kg bw
- Clinical signs:
- No data supplied
- Body weight:
- No data supplied
- Gross pathology:
- No data supplied
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A range of toxicity and irritation results for various epoxy monomers is documented in this report. No consistent correlations with structure are evident.
The median lethal dermal dose was calculated to be >20 ml/kg bw for rabbits - Executive summary:
Carcinogenic and acute toxicity potential of the test material was assayed.
Irritation
The irritation result given is provided for irritation on an uncovered rabbit belly and was given a score of 2.
Toxicity
A wide range of toxicity and irritation of epoxy monomers is documented in this report. No consistent correlations with structure are evident.
Carcinogenicity
The test was successfully completed. The test material was not considered to be tumorigenic to the mouse skin.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of test guidelines or adoption of GLP, however the testing laboratory is reputable and the study design appears to follow methods similar to those adopted subsequently as international standards. Read across to a study result from an investigation using a similar material is justified for members of the Epoxidised Oils and Derivatives group. Four epoxidised oils (linseed, soybean, 2-ethylhexyl tallate and fatty acids, C14-C22, 2-ethylhexylesters) have been identified as sharing common structural and functional similarities, recognised in an OECD SIDS review as a single category, and therefore justifying read-across between data for different members of the group. Consequently data sharing between ESBO epoxidised soybean oil and epoxidised linseed oil is commonly utilised in the preparation of this dossier and other read-across bridges are used for other members of the EOD group where appropriate.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Similar to OECD Guideline 402 or EC Method 403 but as a rangefinding test fewer rabbits used than recommended in formal guidelines adopted many years after study conduct.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: 3-5 months old
- Weight at study initiation: mean weight 2.5 kg
- Fasting period before study: No
- Housing: No data
- Diet (e.g. ad libitum): Rockland rabbit ration
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From:No details provided To: No details provided - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: Impervious 'Vinylite' sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: Exposure period was 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 20 ml/kg bw applied undiluted
- Concentration (if solution): undiluted
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hour occluded exposure
- Doses:
- 20 ml/kg bw
- No. of animals per sex per dose:
- NOt stated, but report wording suggests only four rabbits were treated
- Control animals:
- not specified
- Details on study design:
- No further details available
- Statistics:
- Thompson's method for calculating median lethal doses, used where appropriate
- Preliminary study:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
- Mortality:
- Four rabbits survived treatment at 20 ml/kg bw. It appears that only four rabbits were treated and therefore there were no mortalities.
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- Topical application of 20 ml/kg bw to rabbit skin under fully occluded conditions for 24 hours, resulted in no deaths. All four treated rabbits survived 24 h treatment and the 13 day observation period
- Interpretation of results:
- other:
- Conclusions:
- 24 hour exposure to undiluted ESBO under fully occluded conditions did not result in signs of reaction to treatment, mortality or evidence of dermal toxicity in the four rabbits tested.
- Executive summary:
24 hour exposure to undiluted ESBO under fully occluded conditions did not result in signs of reaction to treatment, mortality or evidence of dermal toxicity in the four rabbits tested.
Referenceopen allclose all
Toxicity
A wide range of toxicity and irritation of epoxy monomers is documented in this report. No consistent correlations with structure are evident.
Range-finding results are reported for a number of acute investigations including oral, dermal and inhalation toxicity, skin and eye irritancy and skin sensitisation potential.
The median lethal oral gavage dose in rats was calculated to be 22.5 mL/kg bw.
Carcinogenicity
The test was successfully completed. The test material was not considered to be tumorigenic to the mouse skin.
Sebaceous Gland Suppression
The mean number of sebaceous glands per square centimeter of skin of epoxide-dosed mice has been graded against that of the control mice. As the material was applied undiluted, it was compared to a distilled water control group. This substance was tested by both the sebaceous gland (S.G.T.) and the lifetime tests (L.T.T.). The L.T.T. was negative, the tumour and the cancer index were both 0.0. It was given a S.G.T. grade of 0.
The authors of this report have indicated that the S.G.T., based on the data in this report, is merely a crude screen to indicate potential L.T.T. tumorigens, not a test to be used to from definite positive or negative conclusions concerning tumorigenesis.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 20 000 mg/kg bw
Additional information
Justification for classification or non-classification
Classification for acute oral toxicity or for acute dermal toxicity under CLP is not triggered, based on the the data available.
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