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EC number: 231-323-7 | CAS number: 7492-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Link to relevant study records
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Principles of method if other than guideline:
- Reprotoxicity test was performed on rats by using citral diethylacetal .
- GLP compliance:
- no
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic - Species:
- rat
- Strain:
- Sprague-Dawley
- Details on species / strain selection:
- No data available
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: gavage
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: Corn oil or methylcellulose
- Details on exposure:
- No data available
- Details on mating procedure:
- - M/F ratio per cage: No data available
- Length of cohabitation: Mention but duration was not given specific
- Proof of pregnancy: [vaginal plug / sperm in vaginal smear] referred to as [day 0 / day 1] of pregnancy No data available
- After ... days of unsuccessful pairing replacement of first male by another male with proven fertility. No data available
- Further matings after two unsuccessful attempts: [no / yes (explain)] No data available
- After successful mating each pregnant female was caged (how): No data available
- Any other deviations from standard protocol: No data available - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data available
- Duration of treatment / exposure:
- approx 46 days
- Frequency of treatment:
- Daily
- Details on study schedule:
- No data available
- Remarks:
- 0, 125, 250 and 500 mg/kg-day
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Positive control:
- No data available
- Parental animals: Observations and examinations:
- Parental animals observation and examinations
CAGE SIDE OBSERVATIONS: No data
- Time schedule: No data
- Cage side observations checked in table [No.?] were included. No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: No data
BODY WEIGHT: Yes
- Time schedule for examinations: No data
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data
- Time schedule for examinations: No data - Oestrous cyclicity (parental animals):
- No data
- Sperm parameters (parental animals):
- No data
- Litter observations:
- Mortality and body weight were examined.
- Postmortem examinations (parental animals):
- Postmortem examinations (Parent Animal)
SACRIFICE
- Male animals: No data available
- Maternal animals: Yes
GROSS NECROPSY
- Yes
HISTOPATHOLOGY / ORGAN WEIGHTS
- Yes - Postmortem examinations (offspring):
- Postmortem examinations (offspring)
SACRIFICE
- Yes
GROSS NECROPSY
- Gross necropsy : Yes
HISTOPATHOLOGY / ORGAN WEIGTHS
-Yes - Statistics:
- No data available
- Reproductive indices:
- No data available
- Offspring viability indices:
- yes, viability on day 4 were observed
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Dams showed clinical signs
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- no effects observed
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- body weight and weight gain
- Remarks on result:
- other: No effect observed
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 250 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- other: No effect
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- other: not specified
- Generation:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Relation to other toxic effects:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Conclusions:
- NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
- Executive summary:
In Combined reproductive/developmental toxicity screening test, Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 0, 125, 250 and 500 mg/kg-day orally by gavage in Corn oil or methylcellulose. Clinical signs and lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls. In addition, no reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day. Decrease in pups body weight were observed at 500 mg/kg-day. Therefore, NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Reference
Body weight: lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls.
Reproductive performance: No reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day as compared to control.
Decrease in pups body weight were observed at 500 mg/kg-day
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Data is Klimisch 4 and from secondary literature
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Reproductive toxicity: Oral
In a study, 1,1-diethoxy-3,7-dimethylocta-2,6-diene has been investigated for reproductive toxicity to a greater or lesser extent. Study based on in vivo experiment in rodents, i.e. most commonly in rat for 1,1-diethoxy-3,7-dimethylocta-2,6-diene.
In a experimental study given by WHO (Who Food Additives Series: 48, Fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) World Health Organization, Geneva, 2002), Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 0, 125, 250 and 500 mg/kg-day orally by gavage in Corn oil or methylcellulose. Clinical signs and lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls. In addition, no reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day. Decrease in pups body weight at 500 mg/kg-day were observed as compared to control. Therefore, NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Thus, based on the above study on 1,1-diethoxy-3,7-dimethylocta-2,6-diene, it can be concluded that NOAEL value is 500 mg/kg bw and no reproductive effect were observed. Thus comparing this value with the criteria of CLP regulation, 1,1-diethoxy-3,7-dimethylocta-2,6-diene can be “Not Classified” for reproductive toxicity.
Effects on developmental toxicity
Description of key information
NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 422
- Principles of method if other than guideline:
- Developmental toxicity test was performed on rats by using citral diethylacetal .
- GLP compliance:
- no
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic - Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- Sex Female
- Route of administration:
- oral: gavage
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: Corn oil or methylcellulose
- Details on exposure:
- No data available
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data available
- Details on mating procedure:
- - M/F ratio per cage: No data available
- Length of cohabitation: Mention but duration was not given specific
- Proof of pregnancy: [vaginal plug / sperm in vaginal smear] referred to as [day 0 / day 1] of pregnancy No data available
- After … days of unsuccessful pairing replacement of first male by another male with proven fertility. No data available
- Further matings after two unsuccessful attempts: [no / yes (explain)] No data available
- After successful mating each pregnant female was caged (how): No data available
- Any other deviations from standard protocol: No data available - Duration of treatment / exposure:
- approx 46 days.
- Frequency of treatment:
- Daily
- Duration of test:
- 7 days prior to cohabitation and through cohabitation, gestation, delivery and day 4 of lactation
- Remarks:
- 0, 125, 250 and 500 mg/kg-day
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Maternal examinations:
- Clinical signs, body weight, food consumption and gross lesions examined.
- Ovaries and uterine content:
- No data available
- Fetal examinations:
- Body weights and body weight gains were observed.
- Statistics:
- No data available
- Indices:
- No data available
- Historical control data:
- No data available
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Number of abortions:
- not specified
- Pre- and post-implantation loss:
- not specified
- Total litter losses by resorption:
- not specified
- Early or late resorptions:
- not specified
- Dead fetuses:
- not specified
- Changes in pregnancy duration:
- not specified
- Description (incidence and severity):
- Migrated Data from removed field(s)
Field "Effects on pregnancy duration" (Path: ENDPOINT_STUDY_RECORD.DevelopmentalToxicityTeratogenicity.ResultsAndDiscussion.ResultsMaternalAnimals.MaternalDevelopmentalToxicity.EffectsOnPregnancyDuration): not specified - Changes in number of pregnant:
- not specified
- Other effects:
- not specified
- Details on maternal toxic effects:
- Clinical signs: Clinical signs were observed in treated female rats at 500 mg/kg bw/ day as compared to control.
Body weight: lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls.
Reproductive performance: No reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day as compared to control. - Dose descriptor:
- NOAEL
- Effect level:
- 125 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Basis for effect level:
- body weight and weight gain
- clinical signs
- other: No effect
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Basis for effect level:
- other: reproductive toxicity
- Abnormalities:
- not specified
- Localisation:
- not specified
- Fetal body weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Migrated Data from removed field(s)
Field "Fetal/pup body weight changes" (Path: ENDPOINT_STUDY_RECORD.DevelopmentalToxicityTeratogenicity.ResultsAndDiscussion.ResultsFetuses.FetalPupBodyWeightChanges): effects observed, treatment-related - Reduction in number of live offspring:
- not specified
- Changes in sex ratio:
- not specified
- Changes in litter size and weights:
- not specified
- Changes in postnatal survival:
- not specified
- External malformations:
- not specified
- Skeletal malformations:
- not specified
- Visceral malformations:
- not specified
- Other effects:
- not specified
- Details on embryotoxic / teratogenic effects:
- Body weight: Lower body weight compared to controls was observed only at 500 mg/kg-day.
- Dose descriptor:
- NOAEL
- Effect level:
- 250 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- fetal/pup body weight changes
- other: No effect observed
- Abnormalities:
- not specified
- Localisation:
- other: not specified
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
- Relation to maternal toxicity:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
- Conclusions:
- NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
- Executive summary:
In Combined reproductive/developmental toxicity screening test, Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 0, 125, 250 and 500 mg/kg-day orally by gavage in Corn oil or methylcellulose. Clinical signs and lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls. In addition, no reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day. But, developmental toxicity was observed as decrease in pups body weight at 500 mg/kg-day. Therefore, NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Data is Klimisch 4 and from secondary literature
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Developmental toxicity: Oral
In a study, 1,1-diethoxy-3,7-dimethylocta-2,6-diene has been investigated for Developmental toxicity to a greater or lesser extent. Study based on in vivo experiment in rodents, i.e. most commonly in rat for 1,1-diethoxy-3,7-dimethylocta-2,6-diene.
In a experimental study given by WHO (Who Food Additives Series: 48, Fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) World Health Organization, Geneva, 2002), Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 0, 125, 250 and 500 mg/kg-day orally by gavage in Corn oil or methylcellulose. Clinical signs and lower body weights and body weight gains were observed at 250 and 500 mg/kg-day as controls. In addition, no reproductive toxicity was observed in treated female rats at 125, 250 and 500 mg/kg-day. But, developmental toxicity was observed as decrease in pups body weight at 500 mg/kg-day. Therefore, NOAEL was considered to be 500 mg/kg-day for p genearrtion and 250 mg/kg-day for F1 generation when Sprague-Dawley female rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally by gavage for approx 46 days.
Thus, based on the above study on 1,1-diethoxy-3,7-dimethylocta-2,6-diene, it can be concluded that NOAEL value is 500 mg/kg bw and no reproductive effect were observed. Thus comparing this value with the criteria of CLP regulation, 1,1-diethoxy-3,7-dimethylocta-2,6-diene can be “Not Classified” for Developmental toxicity.
Justification for classification or non-classification
Based on the above study on 1,1-diethoxy-3,7-dimethylocta-2,6-diene, it can be concluded that NOAEL value is 500 mg/kg bw and no reproductive effect were observed. Thus comparing this value with the criteria of CLP regulation, 1,1-diethoxy-3,7-dimethylocta-2,6-diene can be “Not Classified” for reproductive and Developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.