Registration Dossier
Registration Dossier
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EC number: 221-375-9 | CAS number: 3081-14-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No studies on toxicokinetics of 77PD are available. However, considering the toxicokinetic profile of structural analogues and taking into account the experiences with 77PD in acute and repeated dose toxicity studies, a characterization of 77PD toxicokinetics can be conducted.
77PD is a dark red/magenta liquid (Currenta, 2010) with a low vapour pressure < 1.467*10-6 hPa at 25°C (Monsanto, 1980). The molecular mass of 304.5132 g/mol and calculated value Log Kow 6.3 (Currenta, 2009) suggest intestinal absorption subsequent to oral ingestion. This assumption is confirmed by data from acute oral toxicity studies and a repeated dose toxicity study.
However, acute oral toxicity is moderate, indicated by an oral LD50 value of 730 mg/kg bw in Sprague-Dawley rats (Monsanto Co. 1973); systemic availability was indicated by clinical signs like reduced appetite and activity (lasting 4 to 6 days in survivors), increasing weakness, collapse and death (Monsanto Co. 1973). In addition, in a subacute feeding study bioavailability was indicated by decrease in body weight and body weight gain and changes in haematology, and in clinical chemistry (Monsanto Co. 1989). In a subchronic feeding study, rats treated with 77PD showed changes in body weight, body weight gain and clinical chemistry parameters (Monsanto Co. 1989). In a limited early two-year chronic feeding study with rats (Monsanto Co. 1978) changes in body weight and body weight gain were observed in treated animals. In summary, the data from repeated dose toxicity studies indicated bioavailability of 77PD via the oral route. 77PD showed a very low skin and eye irritating potential (Bayer AG 1990, Monsanto Co. 1973). The acute dermal toxicity is low, indicated by a dermal LD50 value of = 3160 mg/kg bw. The occurrence of clinical signs after dermal application, like reduced appetite and activity (lasting 3 to 7 days in survivors), increasing weakness, collapse and death (2 to 3 days after application) indicates systemic availability after dermal exposure.
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