Registration Dossier
Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21 d, survival and reproduction): 20 µg a.i./L (mean measured, OECD 211, flow-through, based on growth of Daphnia magna)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 20 µg/L
Additional information
One key study investigating the chronic effects of tetramethylthiuram disulfide (CAS No. 137-26-8) to Daphnia magna is available. This test was conducted according to the OECD Guideline No. 211, under GLP conditions. Test organisms were exposed to control, solvent control, 5, 10, 20, 40 and 80 µg a.i./L 14C-thiram (nominal) within a flow-through water regime for 21 days. Survival, reproductive and growth-related effects were recorded. Tetramethylthiuram disulfide (CAS No. 137-26-8) water concentrations were analysed on days 0, 7, 14 and 21. Mean measured concentrations represented 100 to 101% of nominal concentrations. Significant decreases were observed in reproduction and survival at the highest concentration tested, resulting in NOEC (21 d) values of 40 µg a.i./L (mean measured) for both endpoints. Furthermore, there were significant growth-related and sub-lethal effects on daphnids exposed to 40 µg a.i./L (mean measured) test compound and therefore, the lowest NOEC (21 d) values in this test were 20 µg a.i./L (mean measured) for both endpoints.
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