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Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 - 18 March 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP certifying authority, the United Kingdom
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.81
- Temp.:
- 20 °C
- pH:
- 4
- Type:
- log Pow
- Partition coefficient:
- 1.84
- Temp.:
- 20 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- 1.82
- Temp.:
- 20 °C
- pH:
- 9
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 25 January 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.73
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.73
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 September 2005- 5 May 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- - The preliminary estimate of the partition coefficient of the test item was determined using the preliminary EPI SuiteTM v3. 10 software - The water used was Milli-Q water which is 18 megohm (equal or better than ASTM Type 1 water)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Standards Council of Canada and Federation Institute for Consumer Health Protection and Veterinair Medicine (Germany)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.8
- Temp.:
- 40.5 °C
- pH:
- 4
- Type:
- log Pow
- Partition coefficient:
- 2.1
- Temp.:
- 37.5 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- 1.9
- Temp.:
- 40.5 °C
- pH:
- 10
Referenceopen allclose all
The octanol/water partition coefficient of Thiram was found to be 64.3 (log10 Pow = 1.81) in pH 4 buffer solution, 69.2 (log10 Pow = 1.84) in pH 7 buffer solution, and 65.8 (log10 Pow = 1.82) in pH 9 buffer solution at 20 °C.
Temperature and pH are not stated in the report
Temperature and pH are not stated in the report
The partition coefficient of purified thiram is independent of pH in the range of pH 4 to 10
During the determination of the partition coefficient at neutral conditions, the temperature of the column oven was at 37.5 ± 0.1°C and during the determinations at pH 10 and pH 4, the temperature of the column oven was at 40.5 ± 0.3°C which is well within the ± 1°C specified by the test method. For all three pH conditions, there was no ambiguity in assigning retention times to the test item and any of the reference compounds
Description of key information
Log Pow: 1.8-2.1 at pH from 4-10 and temperature from 20 - 40 °C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.84
- at the temperature of:
- 20 °C
Additional information
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