Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish short-term toxicity test on embryo and sac-fry stages
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- "The effect values found are usually very low compared to effect values found by other authors. No explanation for these large discrepancies could be found. It was not possible to reproduce the effect values found in this study. Hence, it was decided not to use these data for a derivation of a PNECaqua if other valid fish early life stage tests are available." From EU-RAR, Nitrobenzene, 2007
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report, Nitrobenzene, CAS No: 98-95-3
- Author:
- European Chemicals Bureau
- Year:
- 2 007
- Bibliographic source:
- 3rd Priority List, Volume: 77
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Aquatic Toxicitiy of Organic Compounds to Embryo-Larval Stages of Fish and Amphibians
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Analytical purity: reagent grade
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- 4 days post-hatching
Test conditions
- Hardness:
- 112.1 ± 1.2 mg/L CaCO3
- Test temperature:
- 14.2 ± 0.1°C
- pH:
- 7.9 ± 0.02
- Dissolved oxygen:
- 9.8 ± 0.1 mg/L
Results and discussion
Effect concentrations
- Duration:
- 23 d
- Dose descriptor:
- LC50
- Effect conc.:
- 0.002 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
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