Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-152-2
CAS no.:
78-87-5
Index number:
Molecular formula:
C3H6Cl2
SMILES:
CC(Cl)CCl
InChI:
InChI=1/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
5
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP09) approved by the European Union, this substance may cause cancer, is a highly flammable liquid and vapour, is harmful if swallowed and is harmful if inhaled.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic if swallowed.

Breakdown of all 203 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Acute Tox. 3 H301
Acute Tox. 3 H331
Eye Irrit. 2 H319
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 4 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, coating products and washing & cleaning products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants, coating products, inks and toners and washing & cleaning products.

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: textile, leather or fur, fabricated metal products and furniture.

This substance is used in the following activities or processes at workplace: batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: adhesives and sealants, coating products, inks and toners and washing & cleaning products.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: adhesives and sealants, coating products, inks and toners and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: chemicals, textile, leather or fur, fabricated metal products, machinery and vehicles and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, industrial spraying, roller or brushing applications, treatment of articles by dipping and pouring and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use explosion-proof equipment (electrical/ventilating/lighting/etc.); wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. If swallowed: call a poison center or doctor/physician if you feel unwell.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Chimcomplex S.A. Borzesti, 3, Industriilor Street 601124 Onesti Bacau Romania
  • DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH, Am Kronberger Hang 4 D-65824 Schwalbach Germany
  • PCC Rokita SA, Sienkiewicza 4 56-120 Brzeg Dolny Poland
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands

Substance names and other identifiers

propylene dichloride
C&L Inventory
1,2-dichloorpropaan (nl)
C&L Inventory
1,2-dichloropropan (pl)
C&L Inventory
1,2-dichloropropane (fr)
C&L Inventory
1,2-dichlorpropan (cs)
C&L Inventory
1,2-dichlorpropanas (lt)
C&L Inventory
1,2-dichlórpropán (sk)
C&L Inventory
1,2-dicloropropano (es)
C&L Inventory
1,2-diclorpropan (ro)
C&L Inventory
1,2-dihlorpropāns (lv)
C&L Inventory
1,2-Diklooripropaani (fi)
C&L Inventory
1,2-dikloropropaan (et)
C&L Inventory
1,2-dikloropropan (hr)
C&L Inventory
1,2-diklorpropan (no)
C&L Inventory
1,2-diklórpropán (hu)
C&L Inventory
1,2-διχλωροπροπάνιο διχλωριούχο προπυλένιο (el)
C&L Inventory
1,2-дихлоропропан (bg)
C&L Inventory
chlorek propylenu (pl)
C&L Inventory
dichlorek propylenu (pl)
C&L Inventory
dichlorure de propylène (fr)
C&L Inventory
dicloreto de propileno (pt)
C&L Inventory
diclorura de propilen (ro)
C&L Inventory
dicloruro de propileno (es)
C&L Inventory
dicloruro di propilene (it)
C&L Inventory
propilen diklorid (hr)
C&L Inventory
propilendichloridas (lt)
C&L Inventory
propilén-diklorid (hu)
C&L Inventory
propilēndihlorīds (lv)
C&L Inventory
propyleendichloride (nl)
C&L Inventory
propylendichlorid (cs)
C&L Inventory
propylendiklorid (no)
C&L Inventory
propyléndichlorid (sk)
C&L Inventory
Propüleendikloriid (et)
C&L Inventory
пропилендихлорид (bg)
C&L Inventory
Propane, 1,2-dichloro-
Other
1,2 dichloropropane
C&L Inventory
propylene dichloride (PDC)
Registration dossier
26198-63-0
Deleted CAS number
Other
602-020-00-0
Index number
C&L Inventory
78-87-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Liquid (100%) [1]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 2 studies processed
R Melting / freezing point
-100.4 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-100.4 - -100.4 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
96.4 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
96.4 - 96.5 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
1.08 - 1.18 g/cm³ @ 0 - 80 °C [6]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.155 - 1.16

Vapour pressure

Study results
  • 5 studies submitted
  • 2 studies processed
R Vapour pressure
18 - 599 hPa @ 0 - 80 °C [5]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
51 - 66.2 hPa @ 20 - 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 3 studies processed
R Log Pow
1.98 - 2.28 @ 20 °C and pH 7 [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2 - 2.25 @ 20 - 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
1.297 - 2.82 g/L @ 20 - 25 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
2.7 - 2.8 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 6 studies submitted
  • 3 studies processed
R Flash point
13 - 21 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
21 °C

Auto flammability

Study results
  • 5 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
555 - 600 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
555 - 556.85 °C

Flammability

Study results
  • 4 studies submitted
  • 2 studies processed
C Interpretation of results
Flammable (50%), Highly flammable (50%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
0.44 - 1.2 [4]
R kinematic viscosity (in mm²/s)
0.551 - 0.757 [3]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
0.757 mm²/s
Dynamic viscosity at 20 °C
0.85 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 8 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
34.9 days [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 1 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
23 - 35 days

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
15.8 - 23.26 years @ 24.85 - 25 °C

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 9 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in sediment
60 days @ 24.85 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
52 days @ 14.85 °C

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
7

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
60.3

Henrys law constant (H)

Study results
  • 5 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
285.736 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.002 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 2
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 82 - 400 µg/L (2)
Intermittent releases (freshwater) 27 - 154 µg/L (2)
Marine water 8.2 - 40 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 590 - 8 600 µg/L (2)
Sediment (freshwater) 676 - 4 150 µg/kg sediment dw (2)
Sediment (marine water) 67.6 - 415 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 87.9 - 600 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 9 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 127 - 140 mg/L [4]
LC50 (72 h) 141 mg/L [2]
LC50 (48 h) 154 mg/L [2]
LC50 (24 h) 194 mg/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
133 - 139 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (32 days) 6 mg/L [1]
NOEC (28 days) 6 - 11 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
6 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 2.7 mg/L [1]
EC50 (24 h) 3.8 mg/L [1]
LC50 (4 days) 24.79 - 26.65 mg/L [2]
LC50 (48 h) 55.9 mg/L [1]
LC50 (24 h) 72.9 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
2.7 - 55.9 mg/L
EC50 / LC50 for marine invertebrates
24.79 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
NOEC (28 days) 4.09 mg/L [2]
NOEC (21 days) 8.3 - 15.8 mg/L [3]
LOEC (21 days) 15.8 - 21.5 mg/L [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
4.09 - 8.3 mg/L
EC10 / LC10 or NOEC for marine invertebrates
4.09 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 7.95 - 18.6 mg/L [4]
NOEC (72 h) 7.95 - 8.5 mg/L [4]
LOEC (72 h) 7.95 mg/L [1]
EC10 (72 h) 5.58 - 11.3 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for marine water algae
15.4 mg/L
EC10 or NOEC for marine water algae
8.5 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
EC50 (30 min) 520 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
59 - 861 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 4.24 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 28.88 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 57.75 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 57.75 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.03 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 2.07 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 1.39 mg/cm² repeated dose toxicity
Acute /short term: (DNEL) 1.39 mg/cm² acute toxicity
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 14.44 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 28.88 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 28.88 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 520 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 1.03 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 690 µg/cm² repeated dose toxicity
Acute /short term: (DNEL) 670 µg/cm² acute toxicity
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 520 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 2.29 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study 3 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
LD50 2 200 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 1 1
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 14 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 2 000 ppm (rat) [1]
M/CInterpretations of results
Harmful [2]

inhalation
Studies with data
Key study 2
Supporting study 8 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 10 100 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed LC50 9 240 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 6 studies processed
P/RResults
NOAEL (rat): 500 mg/kg bw/day [1]
NOAEL (rat): 62 - 250 mg/kg bw (total dose) [2]
NOAEL (mouse): 125 - 500 mg/kg bw (total dose) [2]
NOAEL (monkey): 250 mg/kg bw (total dose) [1]
LOAEL (rat): 1 000 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 6
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 9 studies submitted
  • 2 studies processed
P/RResults
NOAEL (mouse): 15 ppm [1]
LOAEL (rabbit): 150 ppm [1]

Study data: inhalation
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1 1
Supporting study 13 4
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LOAEL 125 mg/kg bw/day (chronic, mouse)
Inhalation route:
Adverse effect observed NOAEC 370 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant