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EC number: 217-157-8 | CAS number: 1758-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitising properties of aminoiminomethanesulphinic acid (CAS 1758-73-2) were tested in a guinea pig maximisation test similar to OECD Guideline 406 (Maurer, 1988).
In the study, Pirbright white guinea pigs (20/group) were induced with 3 pairs of intradermal injections of FCA, 1% test substance in saline and 1% test substance in FCA/saline-adjuvant. Epicutaneous induction was done by application of the test substance at 30% in Vaseline (white petroleum) on the injection site on Day 8. A negative control group was included in the study. Epicutaneous challenge exposure was conducted 20 days after the first induction for 24 h under occlusive conditions. The test substance was applied on the flank at a concentration of 3%. Evaluation of skin reactions was carried out 24 and 48 h after challenge. P-phenylenediammine / potassiumdichromate was included as positive control substance was included in the study.
No skin reactions were observed in any animal in the negative control group. Thus, the available data on skin sensitisation do not provide evidence for sensitising properties of aminoiminomethanesulphinic acid (CAS 1758-73-2) under the conditions of the study.
Migrated from Short description of key information:
OECD 406: non sensitsing
Justification for selection of skin sensitisation endpoint:
There is only one study available.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Justification for selection of respiratory sensitisation endpoint:
Study not required according to Annex VII-X of Regulation (EC) No 1907/2006.
Justification for classification or non-classification
The available data on the skin sensitisation of aminoiminomethanesulphinic acid (CAS 1758-73-2) do not meet the criteria for classification according to Regulation (EC) No 1272/2008 or Directive 67/548/EEC.
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