Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001 - 2002
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide
EC Number:
616-054-9
Cas Number:
74149-74-9
Molecular formula:
C19 H20 N4 O3
IUPAC Name:
N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
white solid substance

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
not specified
Controls:
yes, concurrent no treatment
Duration of treatment / exposure:
4 hours
Observation period:
72 hours sfter dosing
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 1 hour
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 48 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 72 hours
Score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
no irritant effects observed
Executive summary:

Considering the reported data of this irritation study it can be stated that the test item Aminopyriazinon showed no irritant/corrosive effects.