Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 Oral: 1800mg/kg bw (OECD 401, GLP)
LD50 Dermal: >2000mg/kg bw (OECD 402, GLP)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline and GLP compliant study
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EEC, Method B1 OECD Guideline No. 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- other: Rat, Sprague-Dawley
- Vehicle:
- other: 1% Carboxymethylcellulose in distilled water
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 800 mg/kg bw
- 95% CL:
- 1 400 - 2 200
- Remarks on result:
- other: Slope of mortallity curve: 4
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 7; Number of deaths: 0
Male: 800 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 2; Number of deaths: 2
Male: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 3
Male: 2000 mg/kg bw; Number of animals: 10; Number of deaths: 7
Male: 2500 mg/kg bw; Number of animals: 2; Number of deaths: 2
Male: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 5000 mg/kg bw; Number of animals: 10; Number of deaths: 6
Male: 8000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 500 mg/kg bw; Number of animals: 7; Number of deaths: 0
Female: 800 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2000 mg/kg bw; Number of animals: 10; Number of deaths: 5
Female: 2500 mg/kg bw; Number of animals: 2; Number of deaths: 1
Female: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 5000 mg/kg bw; Number of animals: 10; Number of deaths: 7
Female: 8000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- Signs of toxicity related to dose levels:
Mortalities:
Mortalities occured amongst rats dosed at 1260mg/kg and above, within 1 and 47 hours after dosing
Clinical signs:
Signs of reaction to treatment shortly after dosing in all rats were pilo-erection and lethargy.
These were accompanies amongst rats from all groups by hunched posture, abnormal gait, decreased respiratory rate and pallor of the extremities.
Increased salivation was observed in all female rats dosed at 5000mg/kg and two female rats at 8000mg/kg.
A comatose like condition was observed amongst rats dosed at 2000 mg/kg and above.
Gasping was oberved in one female rat dosed at 5000 mg/kg and one female dosed at 8000 mg/kg.
Noisy respiration was observed in one female at 5000 mg/kg and two females at 8000 mg/kg.
Recovery, as judged by external appearance and behaviour, was apparently complete by day 5. - Gross pathology:
- Effects on organs:
Autopsy of animals that had died during the study revealed pallor of the kidneys and spleen. Occasional incidences of haemorrhagic lungs, pallor and patchy livers and pale lungs were also observed.
Terminal autopsy findings were normal. - Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 800 mg/kg bw
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-0000021669-59-0000.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline and GLP compliant study
- Qualifier:
- according to guideline
- Guideline:
- other: Based on OECD Guideline for the Testing of Chemiclas No. 402
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- other: rat, Sprague-Dawley
- Type of coverage:
- occlusive
- Vehicle:
- other: 1% methylcellulose
- Duration of exposure:
- 24 h
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No signs of systemic toxicity were noted during the study period. No toxicologically significant effects on bodyweight were noted during the study. - Gross pathology:
- Effects on organs:
No abnormalities were noted at necropsy of animals killed at the end of the study. - Other findings:
- Signs of toxicity (local):
No signs fo dermal irritation were noted during the study period. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-0000021669-59-0000.
Additional information
Acute Toxicity:Oral
In acute oral toxicity study carried out in male and female Sprague Dawley
rats, (no guideline, GLP) the LD50 was determined to be > =1200 mg/kg bw. In two further acute oral toxicity studies carried out according to a standard acute method (OECD 401 guideline tests, maximum dose 8000mg/kg bw) the LD50 was determined to be 1800 mg/kg bw with a 95% CL of 1400 - 2200 mg/kg bw. Mortalities were evident on both sexes from 1000 mg/kg bw and clinical observations in all animals indicated systemic toxicity. The key study was chosen as the study with the most reliable and adequate results and was the study with no technical errors. The key value was LC50 =1800 mg/kg bw as the lower dose descriptor (>=1200 mg/kg bw) was derived from a study when no adherence to a guideline was reported.
Acute Toxicty: Dermal
In an acute dermal toxicity studies carried out in 5 male and 5 female animals (OECD 402/GLP, semi-occlusive application, 2000mg/kg bw), no deaths occurred and no signs of local toxicity were observed. The LD50 value was
>2000mg/kg bw.
In two acute dermal toxicity studies carried out in 5 male and 5 female animals (guideline limit tests, occlusive application, 2000mg/kg bw), no deaths occurred and no signs of local toxicity were observed. Both tests were carried out in accordance with OECD 402/GLP. The key study was chosen as the study that provided more supporting information. The LD50 value >2000mg/kg bw from the key study was chosen as the key value for the acute dermal toxicity endpoint.Justification for selection of acute toxicity – oral endpoint
OECD Guideline and GLP compliant study. The study with the lowest dose descriptor is of lower quality (not a guideline study).
Justification for selection of acute toxicity – dermal endpoint
OECD Guideline and GLP compliant study
Justification for classification or non-classification
According to the Directive 67/548/EEC, the substance bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc (CAS No. 42405-40-3) is classified as acutely toxic.
Xn, Harmful: R22 Harmful if swallowed
According to the CLP Regulation, the substance bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc (CAS No. 42405-40-3) is classified as: Acute tox 4. Warning, H302: Harmful if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.