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EC number: 217-218-9 | CAS number: 1779-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-02-15 to 2003-06-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- adopted July 17, 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Version / remarks:
- December 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyltriphenylphosphonium bromide
- EC Number:
- 217-218-9
- EC Name:
- Methyltriphenylphosphonium bromide
- Cas Number:
- 1779-49-3
- Molecular formula:
- C19H18P.Br
- IUPAC Name:
- methyl(triphenyl)phosphonium bromide
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): municipal sewage treatment plant: 'Waterschap de Maaskant', ‘s-Hertogenbosch, the Netherlands.
- Storage length: Before use, the sludge was allowed to settle (30-90 minutes) and the liquid decanted for use as inoculum at the amount of 10 mL/L of mineral medium.
- Preparation of inoculum for exposure: The sludge was kept under continuous aeration until further treatment. Mineral components, Milli-RO water (ca. 80% total volume) and inoculum (1% final volume) were added to each bottle. This mixture was aerated with CO2-free air overnight to purge the system of CO2.
- Concentration of sludge: The concentration of suspended solids was 3.1 g/L in the concentrated sludge (information obtained from the municipal sewage treatment plant). - Duration of test (contact time):
- 29 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 19 mg/L
- Based on:
- test mat.
- Initial conc.:
- 12 mg/L
- Based on:
- TOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
Stock solutions of mineral components
A) 8.50 g KH2PO4
21.75 g K2HPO4
67.20 g Na2HPO4 x 12 H2O
0.50 g NH4Cl dissolved in 1 L Milli-Q water, pH 7.4 2 ± 0.2
B) 22.50 g MgSO4 x 7H2O dissolved in 1 L Milli-Q water
C) 36.40 g CaCl2 x 2H2O dissolved in 1 L Milli-Q water.
D) 0.25 g FeCl3 x 6H2O dissolved in 1 L Milli-Q water.
Mineral medium
1 L mineral medium contains: 10 mL of solution (A), 1 mL of solutions (B) to (D) and Milli-RO water.
- Test temperature: 21.4 - 23.5 °C
- pH: at test start: 7.2, at test end: 7.5 - 8.0
- pH adjusted: no
- Suspended solids concentration: 3.1 g/L
- Continuous darkness: yes
SAMPLING
- Sampling frequency: Titrations were made every second or third day during the first 10 days, and thereafter at least every fifth day until the 28th day. Sampling: 0, 2, 5, 7, 9, 14, 19, 23, 27 and 29 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: inoculum blank: containing only inoculum (2 bottles); Test vessels 2 litre all-glass brown coloured bottles.
- Toxicity control: containing test substance, reference substance and inoculum (1 bottle), Test vessels 2 litre all-glass brown coloured bottles.
STATISTICAL METHODS:
The first step in calculating the amount of CO2 produced is to correct for background (endogenous) CO2 production. Thus the amount of CO2 produced by a test material is determined by the difference (in ml of titrant) between the experimental and blank Ba(OH)2 traps.
The amount of 0.05 N HCI titrated is converted into mg of CO2 produced:
mg CO2 = [(0.05 x A ml HCI titrated)/ 2] x 44 = 1.1 x Δ mL of HCI titrated.
Relative degradation values were calculated from the cumulative CO2 production relative to the total expected CO2 production based on the total carbon content of the amount of test material present in the test bottles. They were plotted versus time together with the relative degradation of the positive control.
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 0 d
- Remarks on result:
- other: mean of bottle A and B
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 5 d
- Remarks on result:
- other: mean of bottle A and B
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 2
- Sampling time:
- 14 d
- Remarks on result:
- other: mean of bottle A and B
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 4
- Sampling time:
- 23 d
- Remarks on result:
- other: mean of bottle A and B
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 5
- Sampling time:
- 29 d
- Remarks on result:
- other: mean of bottle A and B
Any other information on results incl. tables
The relative degradation values calculated from the measurements performed during the test period revealed 11 and 1% degradation of methyltriphenylphosphonium bromide for A and B respectively. Thus, the criterion for ready biodegradability (at least 60% biodegradation within the 10 -day window) was not met.
In the toxicity control more than 25% degradation occurred within 14 days (36%, based on ThCO2). Therefore, the test substance was assumed to be not inhibitory to microbial activity.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Methyltriphenylphosphonium bromide was not readily biodegradable under the conditions of the modified Sturm test presently performed.
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