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EC number: 203-479-6 | CAS number: 107-29-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 477 (Genetic Toxicology: Sex-linked Recessive Lethal Test in Drosophila melanogaster)
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- Acetaldehyde oxime
- EC Number:
- 203-479-6
- EC Name:
- Acetaldehyde oxime
- Cas Number:
- 107-29-9
- Molecular formula:
- C2H5NO
- IUPAC Name:
- acetaldehyde oxime
- Details on test material:
- - test material: acetaldehyde oxime (AAO)
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton-S
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Young adult Canton-S males (post-meiotic germ cell stages) and young adult Canton-S males of 1-2 days old (pre-meiotic germ cell stages) were exposed to 2000 ppm AAO by feeding on glass fiber filter paper that had been inundated with either the exposure or control solution. This method also results in contact exposure and inhalation of any fumes that are present. The solvent used is a 5% sucrose solution kept at a pH of 6.8 by a phosphate buffer (1:1 ratio of 4.539 g KH2PO4 per L and 5.938g Na2HPO4.2H2O per L).
- Duration of treatment / exposure:
- 3 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 ppm
Basis:
nominal conc.
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- ethyl methane sulfonate: post-meiotic germ cell stages
dimethylnitrosamine: pre-meiotic germ cell stages
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Genetic testing of acetaldehyde oxime in the Drosophila melanogaster sex-linked recessive lethal test indicates that it is not mutagenic in this organism. There is evidence, however, that AAO may have induced a significant level of sterility in the treated males. - Executive summary:
In the original study on post-meiotic germ cells a cluster of 8 mutants was recovered in the acetyldehyde oxime (AAO) series. In general terms, a cluster constitutes more than one lethal mutation recovered from an individual treated male. In instances where the overall mutation frequency is low, as in the present study, it is not clear that such clusters represent independent mutational events or that they result from a clone of germ cells carrying a prior formed spontaneous mutation. In the former case the mutations would be dispersed over the length of the X chromosome whereas in the latter case they would all occur at the same genetic locus. Unfortunately, the SRLR test does not possess the capability to detect which of these two alternatives is the true situation. When the cluster of 8 was considered as 8 independent events the frequency of mutations in the AAO treated series was significantly elevated above the control frequency. On the other hand, when the cluster was treated as a single prior event the effect of AAO was not significant. The equivocal nature of these data necessitated repeating the experiment. When the data of the second experiment are pooled with those of the first experiment a statistical analysis indicates that AAO did not induce a significant number of mutations. This is true whether the cluster is treated as 8 independent events or a single prior event.
In order to further substantiate that AAO is not mutagenic in higher eukaryotes it was decided to ascertain what effect, if any, it had on spermatogonial cells. These cells are considered to be at highest risk in males because they can accumulate genetic damage over the life time of the organism. Furthermore, they are physiologically different from the post meiotic germ cells in that they are continuously undergoing cell proliferation.
The data clearly show AAO to be non-mutagenic in Drosophila spermatogonial cells. An additional observation that deserves mention, however, is the fact that approximately 23% of the males on test with AAO exhibited complete sterility. This compares to a frequency of 6% in the negative control and is significant.
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