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EC number: 203-714-2 | CAS number: 109-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Methylal
- IUPAC Name:
- Methylal
- Details on test material:
- - Name of test material (as cited in study report): Methylal
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300g
- Fasting period before study: yes (overnight before dosing)
- Diet (e.g. ad libitum): commercial diet ad libitum
- Water (e.g. ad libitum): municipal water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Rats received the test material by stomach intubation with a ball-end stainless steel needle. The test material was injected through the needle with a syringe and doses concentrations were varied by adjusting the volume of the test material or its dilution.
- Doses:
- 1.0, 2.0, 4.0, 8.0, 16.0 mL/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual bodyweight recorded at Days 0 (before dosing), 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and gross pathology - Statistics:
- LD50 are calculated by the moving average method (Thompson, 1947) and are based on a 14-day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7.46 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 5.16 - 10.8
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 423 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths occurred for 5/5 males and 5/5 females at concentration of 16.0 mL/kg bw and for 3/5 males and 3/5 females at concentration of 8.0 mL/kg bw.
- Clinical signs:
- other: Sluggishness, unstendy gait was recorded for both males and females at all concentrations. Prostration, slow or rapid and shallow respiration occured for both male and female rats at concentrations of 4.0, 8.0 and 16.0 ml/kg bw.
- Gross pathology:
- Dark red lungs, livers with tan patches, liquid-filled stomach, red and yellow intestines, black spleens with tan patches and kidney with tan patch were observed among male and female rats from 16.0 mL/kg bw group.
Dark red lungs were observed among dead animals of 8.0 mL/kg bw female rats group.
Lungs with deep red patches were observed among one female rat survivor of dosed 8.0 ml/kg bw group and 2 female rats of dosed 4.0 ml/kg bw group.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test item Methylal is 7.46 ml/kg bw (6453 mg/kg bw) by oral route (gavage) for both male and female rats. Methylal was classified as slighty toxic following single peroral intubation. But non toxic following CLP regulation.
- Executive summary:
Albino Wistar rats were used for this oral acute toxicity test. Animals were fasted overnight before dosing. Municipal water and commercial diet (Agway Prolab Rabbit Ration) were supplied ad libitum.
Rats received the test material by stomach intubation with a ball-end stainless steel needle. The test material was injected through the needle with a syringe and doses concentrations were varied by adjusting the volume of the test material or its dilution.
The test item was applied at levels of 1.0, 2.0, 4.0, 8.0, 16.0 mL/kg bw with 5 animals per sex per dose.
The animals were observed for duration of 14 days following administration. Individual bodyweight was recorded at Days 0 (before dosing), 7 and 14. Signs of toxicity and mortality were recorded. Necropsy of survivors was performed.
Mean body weight increased for survivors of 16.0 ml/ kg bw group and for members of 1.0, 2.0 and 4.0 mL/ kg bw group. Sluggishness, unsteady gait were noted at all concentrations in male and female rats. Prostration, slow or rapid and shallow respiration occurred for both male and female rats at concentrations of 4.0, 8.0 and 16.0 mL/kg bw. Deaths occurred for 5/5 males and 5/5 females at concentration of 16.0 mL/kg bw and for 3/5 males and 3/5 females at concentration of 8.0 mL/kg bw. Dark red lungs, livers with tan patches, liquid-filled stomach, red and yellow intestines, black spleens with tan patches and kidney with tan patch were observed among male and female rats from 16.0 mL/kg bw group. Dark red lungs were observed among victims of dosed 8.0 mL/kg bw female rats group.
The LD50 of the test item Methylal is 7.46 mL/kg bw (6453 mg/kg bw) by oral route (gavage) for both male and female rats. Methylal was classified as slightly toxic following single peroral intubation.
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