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EC number: 947-351-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- ADS 2-5 is not irrtating for eyes
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- For eye irritation, a primary eye irritation study was available (Raltech Scientific Services, 1981b). Based on both the mean and individual scores, cryolite is not considered irritating to the eyes.
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Non-guideline study, limitations in reporting but otherwise adequate for assessment
- Justification for type of information:
- The read-across can be performed because trisodium hexafluoroaluminate is component parts of ADS 2-5, and is the only component with possible negative effects on human health. In view of this fact, we will detail its effect, based on published studies.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
- Remarks:
- The read-across can be performed because trisodium hexafluoroaluminate is component parts of ADS 2-5, and is the only component with possible negative effects for human health
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- For eye irritation, a primary eye irritation study was available (Raltech Scientific Services, 1981b). Based on both the mean and individual scores, cryolite is not considered irritating to the eyes.
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Non-guideline study, limitations in reporting but otherwise adequate for assessment
- Justification for type of information:
- The read-across can be performed because trisodium hexafluoroaluminate is component parts of ADS 2-5, and is the only component with possible negative effects on human health. In view of this fact, we will detail its effect, based on published studies.
- Reason / purpose for cross-reference:
- read-across source
- Remarks:
- The read-across can be performed because trisodium hexafluoroaluminate is component parts of ADS 2-5, and is the only component with possible negative effects for human health
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary eye irritation study
- GLP compliance:
- no
- Specific details on test material used for the study:
- Kryocide Insecticide: NB 84-146-2B
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Young adult rabbits (approximately 14 weeks of age) of the New Zealand White strain were maintained individually in screen bottom cages in temperature and humidity controlled quarters, provided continuous access to commercial laboratory feed and water, and held for acclimation period of at least 7 days.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the contra-lateral eye serving as the untreated control
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- The treated eyes of group II animals (n=3) were flushed for one minute with lukewarm water, starting
30 seconds after test material administration.
The eyes of group I rabbits remained unflushed - Observation period (in vivo):
- 24, 48, 72 and 96 hours and 7 days after treatment
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- Nine acclimated animals were chosen at random for the test. The animals' eyes were examined using fluorescein dy procedures at least 24 hours before compound administration. Only those animals with no sign of corneal injury were used. Animals were divided into two groups: group I with six rabbits and group II with three rabbits.
Each animal received 0.1 g of the finely ground solid sample placed on the everted lower lid of one eye, with the contra-lateral eye serving as the untreated control. The upper and lower lids were gently held together for one second to prevent loss of material and then released, the treated eyes of groupII animals were flushed for one minute with lukewarm water, starting 30 seconds after test material administration. The eyes of group I rabbits remained unflushed.
The treated eyes of both groups were observed for ocular lesions at 24, 48, 72 and 96 hours and at 7 days after treatment. At the 72 hour and 7 day readings, sodium fluorescein and ultraviolet light were used to aid in revealing possible corneal injury. Irritation was graded and scored according to the Draize technique.
Animals were weighed before compound administration and at weekly intervals during the study. At study termination all animals were euthanatized and discarded. - Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96h
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 2
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 7 d
- Score:
- >= 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- other: 96h
- Score:
- >= 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.3
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.7
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.36
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.06
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- other: 96h
- Score:
- 0.5
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.7
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2.7
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.3
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Cryolite is not irritating to the eyes
- Conclusions:
- ADS 2-5 is not irrtating for eyes
ADS 2-5 cannot affect the workers under normal conditions of manufacture, handling, transport and use - Executive summary:
For Cryolite,in accordance to Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for eyes, based on the available data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- Trisodium hexafluoroaluminate
- EC Number:
- 237-410-6
- EC Name:
- Trisodium hexafluoroaluminate
- Cas Number:
- 13775-53-6
- Molecular formula:
- AlF6Na3
- IUPAC Name:
- trisodium hexafluoroalumanetriuide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Cryolite
- Substance type: slighty coloured powder
- Analytical purity: 96.9%
- Composition of test material, percentage of components: Na 31%, Al 12.6%, F 53.3%
- Storage condition of test material: room temperature
impurity 1
- Specific details on test material used for the study:
- Kryocide Insecticide: NB 84-146-2B
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Young adult rabbits (approximately 14 weeks of age) of the New Zealand White strain were maintained individually in screen bottom cages in temperature and humidity controlled quarters, provided continuous access to commercial laboratory feed and water, and held for acclimation period of at least 7 days
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the contra-lateral eye serving as the untreated control
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- The treated eyes of group II animals (n=3) were flushed for one minute with lukewarm water, starting 30 seconds after test material administration.
The eyes of group I rabbits remained unflushed - Observation period (in vivo):
- 24, 48, 72 and 96 hours and 7 days after treatment
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- Nine acclimated animals were chosen at random for the test. The animals' eyes were examined using fluorescein dy procedures at least 24 hours before compound administration. Only those animals with no sign of corneal injury were used. Animals were divided into two groups: group I with six rabbits and group II with three rabbits.
Each animal received 0.1 g of the finely ground solid sample placed on the everted lower lid of one eye, with the contra-lateral eye serving as the untreated control. The upper and lower lids were gently held together for one second to prevent loss of material and then released, the treated eyes of group
II animals were flushed for one minute with lukewarm water, starting 30 seconds after test material administration. The eyes of group I rabbits remained unflushed.
The treated eyes of both groups were observed for ocular lesions at 24, 48, 72 and 96 hours and at 7 days after treatment. At the 72 hour and 7 day readings, sodium fluorescein and ultraviolet light were used to aid in revealing possible corneal injury. Irritation was graded and scored according to the Draize technique.
Animals were weighed before compound administration and at weekly intervals during the study. At study termination all animals were euthanatized and discarded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.24
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96h
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other:
- Remarks:
- Group II (flushed)
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 7 d
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- other: 96h
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.3
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.7
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.36
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.36
- Max. score:
- 4
- Reversibility:
- fully reversible within:
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.06
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other:
- Remarks:
- Group I (unflushed)
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 7 d
- Score:
- >= 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- other: 96 h
- Score:
- 0.5
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.7
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2.7
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other:
- Remarks:
- primary eye irritation scores (Draize)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.3
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The data do not indicate that the substance is an eye irritating substance. Moreover, 0.1 g was administered which is an excess compared to the prescribed amount in current guidelines (0.1 ml).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Cryolite is not irritating for eyes
- Conclusions:
- ADS 2-5 cannot affect the workers under normal conditions of manufacture, handling, transport and use
ADS 2-5 is not irrtating for eyes - Executive summary:
For Cryolite,in accordance to Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for eyes, based on the available data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)