Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from similar mixture/product
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Ethanolamides as Used in Cosmetics
- Year:
- 2 015
- Bibliographic source:
- International Journal of Toxicology 2015, Vol. 34(Supplement 1) 18S-34S - CIR database
Materials and methods
- Principles of method if other than guideline:
- Data are extracted from the 2015 review of the International Journal of Toxicology about the assessment of ethanolamides. Since the studies reported are dated back to 1993 (Andersen FA (ed). Final report on the safety assessment of acet- amide MEA. J Am Coll Toxicol. 1993;12(3):225-236), 2000 (European Commission—European Chemicals Bureau. IUCLID Dataset. N-(2-hydroxyethyl)dodecanamide; 2000. Web site. http://esis.jrc.ec.europa.eu/doc/existing-chemicals/IUCLID/data_ sheets/142789.pdf and European Commission—European Chemicals Bureau. IUCLID dataset. Amides, coco, N-(Hydroxyethyl); 2000. Web site. http://esis.jrc.ec.europa.eu/doc/existing-chemicals/IUCLID/data_ sheets/68140001.pdf. Accessed August 4, 2011), 2004 (Environmental Protection Agency. Appendix 1. Robust summa- ries. ACC FND Amides Category I—FND Amides; 2004. Web site. http://www.epa.gov/hpv/pubs/summaries/fantdrad/c133 19rr.pdf. Summaries of unpublished data) and 2010 (Environmental Protection Agency. Screening-level hazard char- acterization, fatty nitrogen derived (FND) amides category; 2010. Web site. http://www.epa.gov/chemrtk/hpvis/hazchar/Category_ FND%20Amides_September_2010.pdf. Summaries of unpub- lished data) we assume that it was performed according to OECD 401
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethanolamides
- IUPAC Name:
- Ethanolamides
- Test material form:
- solid: granular
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- from 1 to 32 g/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: Cocamide MEA
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Remarks on result:
- other: Cocamide MEA
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 400 mg/kg bw
- Remarks on result:
- other: Cocamide MEA
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 27 000 mg/kg bw
- Remarks on result:
- other: Acetamide MEA
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Lauramide MEA
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not toxic for ingestion according to criteria set out in Regulation (EC) n. 1272/2008 (CLP)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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