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EC number: 433-460-1 | CAS number: 210880-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The main abiotic pathway for degradation of the target compound (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine is photodegradation in soil with a half-life of 8.2 days, while hydrolysis is no relevant degradation process of the test substance and (at 12 °C DT50 = > 1 year at pH 4, pH 7 and pH 9).
A study on the ready biodegradability of the substance is not available. Biodegradation of the substance was investigated in a simulation study with different water/sediment systems. The substance was rapidly transferred from water to sediment, half-lives of the target compound at 20 °C ranged from 48 – 65 days (102 – 138 days, recalculated to 12 °C) in the water/sediment systems. After an incubation period of 100 days 14CO2 accounted for <5% of the initially applied radioactivity.
In a simulation study on the biodegradation of the test compound in water the DT50 was determined to be > 1 year at 20.5 °C.
Three different simulation studies investigating the degradation in a total of ten soil types (sand, loamy sand, sandy loam, loam, silt loam and clay loam). The DT50 values in different soils ranged from 9.7 to 1328 days (32.9 - 2819 days, recalculated to 12 °C) with 9.4 – 29.3% mineralisation after 120 to 379 days.
However, the log Koc value of 2.54 indicates a low potential of the substance for adsorption to soil and sediment particles.
The substance is soluble in water (WS: 0.327 g/L at 20 °C, OECD 105); volatilization from the water phase is not indicated by the Henry's Law Constant of 2.9 Pa m³/mol. Because of the low log Kow (<= 3) the substance is expected to exhibit a low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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