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EC number: 228-207-3 | CAS number: 6168-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
Test material
- Reference substance name:
- DL-2-aminopropan-1-ol
- EC Number:
- 228-207-3
- EC Name:
- DL-2-aminopropan-1-ol
- Cas Number:
- 6168-72-5
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 2-aminopropan-1-ol
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 175, 550, 1750, 5000 mg/kg
- No. of animals per sex per dose:
- 1 to 4
- Control animals:
- no
- Details on study design:
- An initial limit dose of 5000 mg/kg was administered to one healthy female rat by oral gavage.
Pu~ to mortality in this animal, the study proceeded to the Main Test. Using the default starting
level of 175 mg/kg and following the Up and Down procedure, nine additional females were
dosed at levels of 175, 550, 1750 or 5000 mg/kg. Females were selected for the test because they
are frequently more sensitive to the toxicity of test compounds than males. All animals were
observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14
days after dosing or until death occurred. Body weights were recorded prior to administration
(initial) and again on Days 7 and 14 (terminal) following dosing or after death. Necropsies were
performed on all animals.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 750 mg/kg bw
- 95% CL:
- >= 652 - <= 2 690
- Remarks on result:
- other: was also the LDLo
- Mortality:
- Mortality rate at each dose-level (mg/kg):
2/2 at 5000 within one day of exposure
3/4 at 1750 within one day of exposure
0/3 at 550
0/1 at 175 - Clinical signs:
- other: 1750: Prior to death, one animal was hypoactive and exhibited irregular respiration and ataxia. 5000: Prior to death, both animals exhibited irregular respiration and/or ocular discharge. No clinical signs in other animals.
- Gross pathology:
- 1750: Gross necropsy revealed distention and/or discoloration of the stomach and intestines and/or a fluid filled stomach.
5000: Gross necropsy of the decedents revealed discoloration of the intestines and/or liver and distention of the stomach and/or intestines.
No gross abnormalities in other animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
The acute oral LD50 was estimated to be 1750 mg/kg of body weight in female rats with a 95% confidence interval of 651.9-2690 mg/kg.
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