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EC number: 203-464-4 | CAS number: 107-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and quantitative structure–activity relationships of nitriles based on Pseudokirchneriella subcapitata
- Author:
- Chun-Pin Huang, Yun-Ju Wang, Chung-Yuan Chen
- Year:
- 2 007
- Bibliographic source:
- Huang, C.P., Wang, Y.J. & Chen, C.Y., 2007. Toxicity and quantitative structure-activity relationships of nitriles based on Pseudokirchneriella subcapitata. Ecotoxicology and Environmental Safety, 67(3), pp.439–446.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BOD bottles were filled with algae, medium and toxicants to determine the BOD and algal growth rate over time. This method is more applicable for volatile compounds.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Twelve compounds including acetonitrile, chloroacetonitrile, dichlor- oacetonitrile, trichloroacetonitrile, bromoacetoitrile, propionitrile, 3- chloropropionitrile, butyronitrile, isobutyronitrile, 4-chlorobutyronitrile, benzonitrile, and malononitrile were tested in this study. The toxicant concentrations presented in this work are in the form of nominal concentration. All chemicals used were of reagent grade and all tests were performed in triplicate. Stock solutions of toxicants were prepared in foil-wrapped glass containers. Toxicants with low solubility were dissolved in acetone solution. Solvent controls were conducted and the results were checked using t-test at P 1⁄4 0:05. Before commencing the experiment, stock solution was freshly prepared and its concentration was analyzed using a total organic carbon (TOC) analyzer.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: /
- Strain: UTEX 1648
- Source (laboratory, culture collection): not specified
- Age of inoculum (at test initiation): not specified
- Method of cultivation: The alga P. subcapitata (UTEX 1648) was grown in a 4-L transparent chemostat incubator operated under steady state.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Nominal and measured concentrations:
- 14.93, 59.73, 119.45, 238.91, 358.36 and 716.72 mg/L
- Details on test conditions:
- Algal inoculum were withdrawn from the chemostat and transferred into 300-mL BOD bottles, together with dilution water (with growth medium) and toxicants. The BOD bottles were completely filled up with no headspace left. Water seal was provided to ensure a closed test environment. The bottles were then placed on an orbital shaker operated at 100 rpm. Temperature and light intensity were kept at 2471 1C and 65 mEm-2s-1 (710%), respectively. US EPA (1996) bottle medium with no EDTA content was used for toxicity testing. The dilution water was stripped by nitrogen gas to reduce the DO level. In addition, the N2 gas contained 0.5% carbon dioxide as an extra carbon source. The DO level at the beginning of the test was approximately 1–3 mg/L. Two response endpoints were used to evaluate the toxicity of toxicants: DO production (DDO) and algal growth rate based on cell density. The median effective concentration (EC50) was defined as the toxicant concentration that reduced the final DO or algal growth rate to half of that obtained by the control. The initial inoculated cell density was 15 000 cells/mL and the duration of the test was 48 h. A detail description of the test method and the concept of experimental design can be found from the author’s previous work (Lin et al., 2005).
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 223.09 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: dissolved oxygen
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 480.26 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a toxicity test with BOD bottles, which is more applicable for volatile compounds, the effects of propionitrile on Pseudokirchneriella subcapitata were determined. EC50 values were 223 and 480 mg/L for change in DO and growth rate, respectively.
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