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Diss Factsheets
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EC number: 945-920-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March, 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 405). Non GLP. Deviations: lack of study design details in the report, no details on test material, no details on test animals and environmental conditions and the observation period was limited to 7 days. Only a very short description is reported. The main parameters, amount of substance, number of animals, scoring times and scoring system are reliable and thus the result is considered reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- yes
- Remarks:
- lack of study design details in the report, no details on test material, no details on test animals and environmental conditions and the observation period was limited to 7 days
- Principles of method if other than guideline:
- The method of procedure is that suggested by Dr. Draize and described in 'Appraisal of the Saftey of Chemicals in Foods, Drugs and Cosmetics', published by the Association of Food and Drug Officials of the United States.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 266-314-7
- EC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 66327-54-6
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Cas Number:
- 693252-50-5
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Cas Number:
- 76169-46-5
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Cas Number:
- 76169-45-4
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Reference substance name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Reference substance name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 257-942-2
- EC Name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 52475-86-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- 1-Methyl-4-(4-methylpent-3-en-1-yl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C12H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
- Specific details on test material used for the study:
- Vernaldehyde
- Name of test material (as cited in study report): #7155
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- Three normal, healthy, albino rabbits were used in the experiment.
Test system
- Vehicle:
- other: alcoholic propylene glycol
- Controls:
- other: the left eye of each animal remained untreated and served as the reference control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): 2% in 80% alcoholic propylene glycol (by weight) - Duration of treatment / exposure:
- Single instillation on Day 1.
- Observation period (in vivo):
- The eyes of each animal were examined approximately 24, 48, 72 and 96 hours and 7 days after instillation of the test substance
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- STUDY DESIGN
No data
TREATMENT
Each animal had 0.1 mL of the diluted test sample instilled into the right eye with no further treatemt.
REMOVAL OF TEST SUBSTANCE
Washing: No
OBSERVATIONS
The scorings recorded were made according to the Draize scale for scoring ocular lesions (according to OECD).
The scorings were made according to the Draize scale for scoring ocular lesions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No irritation was observed in the treated eyes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute eye irritation/corrosion study with albino rabbits, performed equivalent to OECD 405 test guideline, no irritation was observed with the diluted substance.
- Executive summary:
The diluted test substance (2% in 80% alcoholic propylene glycol) was tested in an acute eye irritation/corrosion study in 3 albino rabbits, performed equivalent to OECD 405 test guideline. No irritation was observed.
Based on the results, the diluted test substance does not have to be classified for eye irritation. No conclusions can be drawn on the 100% test substance.
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