Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 949-881-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- This study was conducted between 07 December 2016 and 04 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability 1 is assigned because the study conducted according to OECD TG 301F in compliance with GLP, without deviations that influence the quality of the results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.3110 (Ready Biodegradability)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of Ethyl 3-(cyclohex-1-en-1-yl) propanoate and Ethyl 3-(cyclohex-2-en-1-yl) propanoate
- EC Number:
- 949-881-1
- Molecular formula:
- C11H18O2
- IUPAC Name:
- Reaction mass of Ethyl 3-(cyclohex-1-en-1-yl) propanoate and Ethyl 3-(cyclohex-2-en-1-yl) propanoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Information as provided by the Sponsor. A Certificate of Analysis supplied by the Sponsor is available.
Identification: FRET 11-0078
Trade Name: IFF FRET 11-0078 (multi-constituent)
IPC Number: 090309
Physical state/Appearance: clear colorless liquid
IUPAC Names of Constituents Ethyl 3-(cyclohex-1-en-1-yl) propanoate Ethyl 3-(cyclohex-2-en-1-yl) propanoate
CAS Number: 65173-43-5 109976-49-0
CAS Name of Constituents: 1-Cyclohexene-1-propanoic acid, ethyl ester 2-Cyclohexene-1-propanoic acid, ethyl ester
Batch/Lot Number: NG342-12
Molecular Formula: C11H18O2 C11H18O2
Molecular Weight: 182.12 182.12
Concentration of Tested Sample: 96.6%
Expiry Date: 01 September 2017
Storage Conditions: approximately 4 °C in the dark
Intended use/Application: fragrance ingredient
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- A mixed population of sewage treatment micro-organisms was obtained on 1 December 2016 from the final effluent stage of the Severn Trent Water Plc sewage treatment plant at Loughborough, Leicestershire, UK, which treats predominantly domestic sewage.
Preparation of Inoculum
The sample of effluent was filtered through coarse filter paper (first approximate 200 mL discarded) and maintained on aeration in a temperature controlled room at 21 ± 1 ºC prior to use. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- other: Biological Oxygen Demand (BOD)
- Details on study design:
- Dissiminated (delete when editing): Look into puzzle pieces and add what is necessary to evaluate the test
Reference substance
- Reference substance:
- other: Dissiminated (delete when editing) add what is applicable
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 21
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- The toxicity control attained 26% biodegradation after 14 days and 43% biodegradation after 28 days thereby confirming that the test item was not toxic to the sewage treatment micro-organisms used in the test.
Aniline (procedure control) attained 69% biodegradation after 14 days and 67% biodegradation after 28 days thereby confirming the suitability of the inoculum and test conditions.
Any other information on results incl. tables
Percentage Biodegradation Values:
Day | % Bioodegradation | ||
Procedure Control | Test Item (mean value, n=2) | Toxicity Control | |
0 | 0 | 0 | 0 |
1 | 0 | 1 | 1 |
2 | 0 | 1 | 1 |
3 | -1 | 0 | 0 |
4 | -4 | 0 | 3 |
5 | 6 | 0 | 9 |
6 | 25 | 0 | 19 |
7 | 43 | 0 | 22 |
8 | 52 | 1 | 23 |
9 | 54 | 2 | 23 |
10 | 62 | 4 | 23 |
11 | 64 | 8 | 24 |
12 | 66 | 9 | 24 |
13 | 68 | 10 | 25 |
14 | 69 | 11 | 27 |
16 | 69 | 12 | 28 |
17 | 69 | 13 | 29 |
18 | 69 | 14 | 30 |
19 | 69 | 15 | 31 |
20 | 68 | 16 | 32 |
21 | 68 | 17 | 66 |
22 | 68 | 18 | 64 |
23 | 68 | 19 | 35 |
24 | 68 | 20 | 37 |
25 | 68 | 20 | 38 |
26 | 67 | 21 | 40 |
27 | 67 | 21 | 42 |
28 | 67 | 21 | 43 |
Validation Criteria
The mean BOD of the inoculated mineral medium (control) was 46.35 mg O2/L after 28 days and therefore satisfied the validation criterion given in the OECD Test Guidelines.
The pH of the inoculated test item vessels on Day 28 ranged from 7.5 to 7.6 and hence satisfied the validation criterion given in the OECD Test Guidelines.
The difference between extremes of replicate BOD values at the end of the test was less than 20% and therefore satisfied the validation criterion given in the OECD Test Guidelines.
Biodegradation
The test item attained 21% biodegradation after 28 days, calculated from the oxygen consumption values, and therefore cannot be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301F.
The toxicity control attained 26% biodegradation after 14 days and 43% biodegradation after 28 days thereby confirming that the test item was not toxic to the sewage treatment micro-organisms used in the test.
Aniline (procedure control) attained 69% biodegradation after 14 days and 67% biodegradation after 28 days thereby confirming the suitability of the inoculum and test conditions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- All validation criteria were satisfied
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The substance showed 21% biodegradation in an OECD TG 301F test and is considered to be not readily biodegradable.
- Executive summary:
The study was performed to assess the ready biodegradability of the test item in an aerobic aqueous media. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (1992) No. 301F, “Ready Biodegradability; Manometric Respirometry Test” referenced as method C.4-D of Commission Regulation (EC) No. 440/2008 and US EPA Fate, Transport, and Transformation Test Guidelines OCSPP 835.3110 (Paragraph (q)).
Methods
The test item at a concentration of 100 mg/L was exposed to sewage treatment micro-organisms with mineral medium in sealed culture vessels in diffuse light at temperatures of between 19 to 21 ºC for 28 days.
The biodegradation of the test item was assessed by the measurement of daily oxygen consumption values on Days 0 to 28. Control solutions with inoculum and the reference item, aniline, together with a toxicity control were used for validation purposes.
Results
The test item attained 21% biodegradation after 28 days and therefore cannot be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline
No. 301F.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.