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EC number: 245-044-3 | CAS number: 22504-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 17 July 1992
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at 0, 96 h and 24 h, 48 h, 72 h (before and after test solution renewal)
- Vehicle:
- yes
- Remarks:
- test water
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Source: Guangzhou Yangshi breeding farm
- Length at study initiation (length definition, mean, range and SD): 2.0-4.0 cm
ACCLIMATION
- Acclimation period: 23 days
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: 3 times per day until 24 h before test
- Health during acclimation (any mortality observed): 0.9% mortality during 7 days preceding the test
FEEDING DURING TEST : no - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 111 mg CaCO3/L
- Test temperature:
- 21.2 - 22.9 °C
- pH:
- 7.41 - 7.90
- Dissolved oxygen:
- min. 60% of air saturation value
- Nominal and measured concentrations:
- Nominal: 0.26, 0.36, 0.51, 0.71, 1.0 mg/L
Measured: 0.0492, 0.0580, 0.0677, 0.0819, 0.0936 mg/L (geometric means) - Details on test conditions:
- 14 h light / 10 h darkness
Mortality and visible abnormalities were recorded at 3, 24, 48, 72, and 96 h after the start of the test - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 59.4 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 81.9 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 0.049 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: spasmodic swimming, reduced activity, overturn and loss of equlibrium were observed at all dose levels
- Observations on body length and weight: no effects
- Other biological observations: none
- Mortality of control: no effects
- Other adverse effects control: no effects
- Abnormal responses:no effects
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no effects
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- K2Cr2O7: 24-h LC50 = 282 mg/L, 95% CI: 251 - 318 mg/L (LC50 validity range: 200 - 400 mg/L)
- Reported statistics and error estimates:
- 96-h LC50 = 0.0594 mg/L, 95% CI: 0.0568 - 0.0621 mg/L
- Sublethal observations / clinical signs:
Nominal conc. (mg/L)
No. of fish in group
Cumulative mortality (%) after (h)
3
24
48
72
96
0
21
0
0
0
0
0
0.26
21
0
0
0
4.8
4.8
0.36
21
4.8
4.8
29
38
37
0.51
21
38
67
90
90
90
0.71
21
81
100
100
100
100
1.0
21
100
100
100
100
100
- Validity criteria fulfilled:
- yes
- Remarks:
- mortality of controls < 10% (0%), dissolved oxygen >60% (80-100%), the measured concetrations (geomean) are used since these were outside the 80-120% window
- Conclusions:
- 96 hLC50 = 0.42 mg/L, nominal
- Executive summary:
The short-term toxicity of GDMP to zebra fish (Brachydanio rerio) was assessed in a study according to OECD TG 203. The fish were exposed to five test concentrations of 0.26, 0.36, 0.51, 0.71 and 1.0 mg/L (nominal) of the test item under semi-static conditions (renewal every 24 h).
The cumulative mortality was 0% at the end of the test. The cumulative mortality in teh 0.26, 0.36, 0.51, 0.71 and 1.0 mg/Lgroups was 4.8, 38, 90, 100 and 100%, respectively.No abnormal sublethal responsed were observed in the control. Behavioural abnormalities including spasmodic swimming, reduced activity, overturn and loss of equlibrium were observed at all concentrations levels.
Under the conditions of this test, the 96 h LC50 to Danio rerio was 0.0594 mg/L (mean, meas.).
Since measured values don't represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase.
As the transformation products are less toxic than the parent substances (no free –SH groups) regulatory endpoints calculated on the basis of nominal concentrations represent a realistic worst case approach. Moreover, for thiochemicals nominal concentrations represent the real environmental conditions, because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. The effect values therefore reflect the toxicity of the system – in the sense of the UVCB approach – rather than the toxicity of the original chemical substance. Under these conditions it is more meaningful to assess their toxicities on the basis of nominal concentrations instead of measured concentrations during exposure. This may better correspond to the situation under environmental conditions as recommended for multi-component-substances (OECD23).
The 96 h LC50 based on nominal concentrations was determined to be 0.42 mg/L.
Reference
Description of key information
The 96 h LC50 based on nominal concentrations was determined to be 0.42 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 0.42 mg/L
Additional information
The short-term toxicity of GDMP to zebra fish (Brachydanio rerio) was assessed in a study according to OECD TG 203. The fish were exposed to five test concentrations of 0.26, 0.36, 0.51, 0.71 and 1.0 mg/L (nominal) of the test item under semi-static conditions (renewal every 24 h).
The cumulative mortality was 0% at the end of the test. The cumulative mortality in teh 0.26, 0.36, 0.51, 0.71 and 1.0 mg/Lgroups was 4.8, 38, 90, 100 and 100%, respectively.No abnormal sublethal responsed were observed in the control. Behavioural abnormalities including spasmodic swimming, reduced activity, overturn and loss of equlibrium were observed at all concentrations levels.
Under the conditions of this test, the 96 h LC50 to Danio rerio was 0.0594 mg/L (mean, meas.).
Since measured values don't represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase.
As the transformation products are less toxic than the parent substances (no free –SH groups) regulatory endpoints calculated on the basis of nominal concentrations represent a realistic worst case approach. Moreover, for thiochemicals nominal concentrations represent the real environmental conditions, because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. The effect values therefore reflect the toxicity of the system – in the sense of the UVCB approach – rather than the toxicity of the original chemical substance. Under these conditions it is more meaningful to assess their toxicities on the basis of nominal concentrations instead of measured concentrations during exposure. This may better correspond to the situation under environmental conditions as recommended for multi-component-substances (OECD23).
The 96 h LC50 based on nominal concentrations was determined to be 0.42 mg/L.
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