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EC number: 226-149-3 | CAS number: 5303-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 787 mg/kg sediment dw
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- emergence rate
- Remarks:
- and sex ratio
- Remarks on result:
- other:
- Remarks:
- Source: CAS 36528-28-6
- Conclusions:
- The key value retained for the toxicity of the target substance ocytl laurate (CAS 5303-24-2) to sediment organisms is a NOEC (28 d) of ≥ 787 mg/kg sediment dw, indicating no effects up to the highest tested concentration based on experimental results from the source substance decyl laurate (CAS 36528-28-6) (OECD 218, C. riparius, 28 d); read-across.
Reference
Description of key information
NOEC (28 d) ≥ 787 mg/kg sediment dw (geom. mean measured, OECD 218, C. riparius), read-across
Key value for chemical safety assessment
Additional information
No experimental study is available, in which the sediment toxicity of the target substance octyl laurate (CAS 5303-24-2) was assessed.Therefore, read-across to the structurally related source substance decyl laurate (CAS 36528-28-6) was conductedin accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by similar fatty acid and alcohol components and is therefore considered a suitable representative for the assessment of the toxicity of the target substance to sediment organisms. A detailed justification of the analogue approach is provided in IUCLID section 13.
In the available study with the source substance decyl laurate (CAS 36528-28-6), a static sediment-freshwater toxicity test according to OECD guideline 218 and GLP was performed in which the model organism Chironomus riparius, a widespread sediment-dwelling midge in freshwater habitats, was exposed to the nominal test item concentrations of 62.5, 125, 250, 500 and 1000 mg/kg sediment dry weight for 28 d via spiked artificial soil. A sediment spiking method was selected because the most likely entry route into the aquatic environment is expected to occur via particulate material carrying adsorbed substance. The artificial sediment was formulated from sand, kaolinite, calcium carbonate and finely sieved sphagnum moss peat according to the guideline, resulting in a final organic carbon content of 2.89%, slightly above the 2.0 ± 0.5%, as recommended by the guideline. Nevertheless, the organic matter content of 4.93% is nearly in line with the recommendations given in ECHA Guidance R.7b (5%; ECHA, 2017). The sediment was spiked by adding 10 mL of the test substance dissolved in the solvent Tetrahydrofuran to the dry sand component of the sediment only, which was allowed to evaporate overnight. Subsequently, all sediment components were combined, liquefied with reconstituted water and mixed on a tumble mill overnight. The spiked sediment was then dispensed to the test vessels, covered with overlying water (reconstituted) and allowed to equilibrate for 7 d prior test start. A control and solvent control (Tetrahydrofuran) were included in the test design. The measured endpoints included effects of the test item on larval development and emergence, effects on the sex ratio of emerged adult insects, development rates and on the time to first emergence. The actual test item concentrations in the sediment and overlying water were analytically verified by GC-MS/HPLC on Day -7 (for sediment only), 0, 7 and 28.
The measured test item concentrations in wet sediment was 90 – 95% of nominal on Day -7, 67-80% of nominal on Day 0, 61 – 88% on Day 7 and 40 – 59% on Day 28. The measured test item concentrations in the overlying water was < LOQ on Day 0, 7 and 28. Based on these findings, the effect values were based on the geometric mean measured test item concentrations in the sediment, resulting in test item exposure concentrations of 39.7, 81.3, 176, 383 and 787 mg/kg sediment dry weight.
At the end of the test, no statistical differences between the control and solvent control was found for any endpoint and all statistical comparisons were made against the solvent control. After 28 d exposure, no significant differences between the total emergence of adults, sex ratio and development rates in the treatments and solvent control were found. The mean times to first emergence ranged from 15 to 17 d, which was similar to that of the controls (15 and 15.5 d, respectively) but was not statistically analyzed.
Thus, the test resulted in an overall NOEC (28 d) of ≥ 787 mg/kg sediment dw (highest exposure concentration) based on development rates, total number of emerged adult insects and their sex ratio. The LOEC (28 d) was > 787 mg/kg sediment dw for all endpoints.
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