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EC number: 279-242-6 | CAS number: 79720-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-dodecyl-1-(2,2,6,6-tetramethyl-4-piperidyl)pyrrolidine-2,5-dione
- EC Number:
- 279-242-6
- EC Name:
- 3-dodecyl-1-(2,2,6,6-tetramethyl-4-piperidyl)pyrrolidine-2,5-dione
- Cas Number:
- 79720-19-7
- Molecular formula:
- C25H46N2O2
- IUPAC Name:
- 3-dodecyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)pyrrolidine-2,5-dione
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: small white Russian, Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Karl Thomae GmbH, Biberach
- Weight at study initiation: 2.1 - 2.4 kg
- Housing:individually in stainless stell cages
- Diet (e.g. ad libitum): K4 Alleindiät für Kaninchen, Ssniff Spezialfutter GmbH, Soest, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+/-1 °C
- Humidity (%): 60+/-5%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES:
From: 31.07. To: 06.08.1984
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml of the test product to approx. 6 cm² skin area.
- Duration of treatment / exposure:
- Skin reaction was assessed and recorded at 1 and 24 h after removal of the dressing and after 48 h and 72 h and after 6 days.
- Observation period:
- 6 days
- Number of animals:
- 3 males, 3 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: area of application grey-white, edges of the area of application dark red; area of application with yellow-brown spots (2 animals); area of application with red-brown spots (1 animal)
- Irritation parameter:
- erythema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: area of application grey-white, edges of the area of application dark red; area of application with red-brown spots; induration of the area of application
- Irritation parameter:
- erythema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: induration of the area of application; severe necrosis with vesiculation over the entire area of application; edges of the area of application dark red (1 animal)
- Irritation parameter:
- erythema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- other: 6 days
- Reversibility:
- not specified
- Remarks on result:
- other: severe necrosis with vesiculation over the entire area of application
- Irritation parameter:
- erythema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: area of application grey-white, edges of the area of application dark red; area of application with yellow-brown spots (2 animals); area of application with red-brown spots (1 animal)
- Irritation parameter:
- erythema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: area of application grey-white, edges of the area of application dark red; area of application with red-brown spots; induration of the area of application
- Irritation parameter:
- erythema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: edges of the area of application dark red (2 animals); induration of the area of application; severe necrosis with vesiculation over the entire area of application
- Irritation parameter:
- erythema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- other: 6 days
- Reversibility:
- not specified
- Remarks on result:
- other: severe necrosis with vesiculation over the entire area of application
- Irritation parameter:
- edema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- males
- Basis:
- mean
- Time point:
- other: 6 days
- Reversibility:
- not specified
- Remarks on result:
- other: open weeping wounds, bleeding cracks
- Irritation parameter:
- edema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- females
- Basis:
- mean
- Time point:
- other: 6 days
- Reversibility:
- not specified
- Remarks on result:
- other: open weeping wounds, bleeding cracks
Any other information on results incl. tables
After 6 days, the experiment was terminated due to severe effects.
The irritation index was 6.13/8 and hence a single dermal application of 0.5 ml of the product is very irritant for male and female rabbits.
Evaluation in accordance with Appendix VI of the Sixth Amendment (79/831/EEC):
Erythema: x = 4.0
Oedema: x = 2.78
There was necrosis formation after an exposure time of only 3 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- The substance is skin corrosive.
- Executive summary:
The substance is skin corrosive.
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