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EC number: 919-489-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-02-13 to 1989-02-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of (2E)-Tridec-2-enenitrile and (2Z)-Tridec-2-enenitrile and (3E)-Tridec-3-enenitrile and (3Z)-Tridec-3-enenitrile
- EC Number:
- 919-489-5
- Molecular formula:
- C13H23N
- IUPAC Name:
- Reaction mass of (2E)-Tridec-2-enenitrile and (2Z)-Tridec-2-enenitrile and (3E)-Tridec-3-enenitrile and (3Z)-Tridec-3-enenitrile
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: females: 121-148 g, males: 150-177 g
- Housing: individually in tiered, stainless steel animal cages
- Diet: ad libitum, no food during exposure
- Water: ad libitum, no water during exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.2 °C during exposure
- Humidity (%): 42.2 during exposure
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: modular glass sections: cylindrical central animal exposure section of 11.45 L volume with top and bottom end cones of 3.31 L volume
- Exposure chamber volume: total chamber volume of 18.07 L, about 33 air change equivalents per hour
- Source and rate of air: 10 L/min
- Treatment of exhaust air: exhaust air was passed through an activated charcoal filter
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- the chamber concentration was checked in 15 minute intervals
- Duration of exposure:
- 4 h
- Concentrations:
- nominal concentration: 7.8 ppm, corresponding to 62.5 mg/m^3 (calculated by the weight of the test substance divided by the volume of air passing through the exposure system)
measured concentration: 6.1 ppm (48.6 mg/m^3)
control group: 0 mg/m^3 - No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weights were recorded on the day of exposure and on the following days 2, 3, 4, 8 and 15 (postmortem). The animals were observed at least twice during working days and at least once at weekends for adverse toxicological effects.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology (kidneys, liver, lungs and spleen were taken for histological examination), other: food consumption was measured at weekly intervals
- The target vapour concentration was 7 ppm, which was the maximum concentration that could be generated at room temperature, as determined in preliminary experiments without animals. - Statistics:
- Body weights and organ weights were analysed for statistically significant differences using the Student's t-test.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.1 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 6.1 ppm corresponds to 48.6 mg/m^3
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No adverse effects were observed.
- Body weight:
- No statistically significant differences were observed between the test and control group.
- Gross pathology:
- No changes were detected.
- Other findings:
- - Organ weights: No statistically significant differences were observed in the organs when related to the body weights.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 value of the test substance as a vapour was determined to be > 6.1 ppm (corresponding to 48.6 mg/m^3), which is the saturated vapour concentration.
- Executive summary:
The test substance was assessed for its acute toxicity after single inhalation exposure in a 4 -hours experiment according to OECD 403. 10 Wistar rats (5 males and 5 females) were exposed to the test substance as a saturated vapour (48.6 mg/m^3) in an exposure chamber. Additionally a control group of 20 animals were exposed to air only. The exposure period was followed by a 14 -day observation period. The animals were observed and body weights were recorded at regular intervals. After 14 days, all animals were killed and subjected to post-mortem examination. The kidneys, liver, lungs and spleen were taken for histological examination. All rats survived the treatment without exhibiting clinical symptoms. No abnormalities were found at necropsy and no statistically significant differences between exposure and control group were found with regard to body weight gains or organ weights. As a conclusion, saturated vapour (48.6 mg/m^3) of the test substance was not toxic in this experiment. Therefore the LD50 was determined to be > 6.1 ppm (corresponding to 48.6 mg/m^3).
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